Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer

DNA immune recognition regulation mediated by the cGAS-STING pathway plays an important role in immune functions. Under normal physiological conditions, cGAS can recognize and bind to invading pathogen DNA and activate the innate immune response. On the other hand, abnormal activation of cGAS or STI...

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Autores principales:	Qiumei Li, Shuoran Tian, Jiadi Liang, Jiqiang Fan, Junzhong Lai, Qi Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	innate immunity cGAS-STING pathway autoimmune disease cancer therapeutic development Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/9dbc2b150e3c497f8479393bf5fd7fa4
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spelling	oai:doaj.org-article:9dbc2b150e3c497f8479393bf5fd7fa42021-11-15T06:03:12ZTherapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer1663-981210.3389/fphar.2021.779425https://doaj.org/article/9dbc2b150e3c497f8479393bf5fd7fa42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.779425/fullhttps://doaj.org/toc/1663-9812DNA immune recognition regulation mediated by the cGAS-STING pathway plays an important role in immune functions. Under normal physiological conditions, cGAS can recognize and bind to invading pathogen DNA and activate the innate immune response. On the other hand, abnormal activation of cGAS or STING is closely related to autoimmune diseases. In addition, activation of STING proteins as a bridge connecting innate immunity and adaptive immunity can effectively restrain tumor growth. Therefore, targeting the cGAS-STING pathway can alleviate autoimmune symptoms and be a potential drug target for treating cancer. This article summarizes the current progress on cGAS-STING pathway modulators and lays the foundation for further investigating therapeutic development in autoimmune diseases and tumors.Qiumei LiShuoran TianJiadi LiangJiqiang FanJunzhong LaiQi ChenFrontiers Media S.A.articleinnate immunitycGAS-STING pathwayautoimmune diseasecancertherapeutic developmentTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	innate immunity cGAS-STING pathway autoimmune disease cancer therapeutic development Therapeutics. Pharmacology RM1-950
spellingShingle	innate immunity cGAS-STING pathway autoimmune disease cancer therapeutic development Therapeutics. Pharmacology RM1-950 Qiumei Li Shuoran Tian Jiadi Liang Jiqiang Fan Junzhong Lai Qi Chen Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
description	DNA immune recognition regulation mediated by the cGAS-STING pathway plays an important role in immune functions. Under normal physiological conditions, cGAS can recognize and bind to invading pathogen DNA and activate the innate immune response. On the other hand, abnormal activation of cGAS or STING is closely related to autoimmune diseases. In addition, activation of STING proteins as a bridge connecting innate immunity and adaptive immunity can effectively restrain tumor growth. Therefore, targeting the cGAS-STING pathway can alleviate autoimmune symptoms and be a potential drug target for treating cancer. This article summarizes the current progress on cGAS-STING pathway modulators and lays the foundation for further investigating therapeutic development in autoimmune diseases and tumors.
format	article
author	Qiumei Li Shuoran Tian Jiadi Liang Jiqiang Fan Junzhong Lai Qi Chen
author_facet	Qiumei Li Shuoran Tian Jiadi Liang Jiqiang Fan Junzhong Lai Qi Chen
author_sort	Qiumei Li
title	Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
title_short	Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
title_full	Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
title_fullStr	Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
title_full_unstemmed	Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer
title_sort	therapeutic development by targeting the cgas-sting pathway in autoimmune disease and cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9dbc2b150e3c497f8479393bf5fd7fa4
work_keys_str_mv	AT qiumeili therapeuticdevelopmentbytargetingthecgasstingpathwayinautoimmunediseaseandcancer AT shuorantian therapeuticdevelopmentbytargetingthecgasstingpathwayinautoimmunediseaseandcancer AT jiadiliang therapeuticdevelopmentbytargetingthecgasstingpathwayinautoimmunediseaseandcancer AT jiqiangfan therapeuticdevelopmentbytargetingthecgasstingpathwayinautoimmunediseaseandcancer AT junzhonglai therapeuticdevelopmentbytargetingthecgasstingpathwayinautoimmunediseaseandcancer AT qichen therapeuticdevelopmentbytargetingthecgasstingpathwayinautoimmunediseaseandcancer
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Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer

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