Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.

<h4>Background</h4>Lipoprotein-associated phospholipase A2 (LpPLA2) levels are associated with stroke, though whether this extends to all populations and stroke subtypes is unknown.<h4>Methods</h4>Serum samples from stroke-free community participants in the Northern Manhattan...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mira Katan, Yeseon P Moon, Myunghee C Paik, Robert L Wolfert, Ralph L Sacco, Mitchell S V Elkind
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9dc09fac60114a3698be6075e3f27a89
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9dc09fac60114a3698be6075e3f27a89
record_format	dspace
spelling	oai:doaj.org-article:9dc09fac60114a3698be6075e3f27a892021-11-18T08:38:15ZLipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.1932-620310.1371/journal.pone.0083393https://doaj.org/article/9dc09fac60114a3698be6075e3f27a892014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24416164/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Lipoprotein-associated phospholipase A2 (LpPLA2) levels are associated with stroke, though whether this extends to all populations and stroke subtypes is unknown.<h4>Methods</h4>Serum samples from stroke-free community participants in the Northern Manhattan Study were assayed for LpPLA2 mass and activity. Participants were followed annually for stroke. Cox-proportional-hazard models were fitted to estimate hazard-ratios and 95% confidence intervals (HR, 95% CI) for the association of LpPLA2 levels with ischemic stroke (IS), after adjusting for demographic and medical risk factors.<h4>Results</h4>Serum samples were available in 1946 participants, of whom 151 (7.8%) experienced a first IS during median follow-up 11 years. Mean age was 69 (SD 10), 35.6% were men, 20% non-Hispanic Whites, 22% non-Hispanic Blacks, and 55% Hispanics. LpPLA2 mass and activity levels were not associated with overall IS risk. LpPLA2 mass but not activity levels were associated with strokes due to large artery atherosclerosis (LAA; adjusted HR per SD 1.55, 95% CI 1.17-2.04). There was a dose-response relationship with LAA (compared to first quartile, 2nd quartile HR = 1.43, 95% CI 0.23-8.64; 3rd quartile HR = 4.47, 95% CI 0.93-21.54; 4th quartile HR = 5.07, 95% CI 1.07-24.06). The associations between LpPLA2-mass and LAA-stroke risk differed by race-ethnicity (p = 0.01); LpPLA2-mass was associated with increased risk of LAA among non-Hispanic Whites (adjusted HR per SD 1.44, 95% CI 0.98-2.11), but not other race-ethnic groups.<h4>Conclusion</h4>LpPLA2-mass levels were associated with risk of atherosclerotic stroke among non-Hispanic White participants, but not in other race-ethnic groups in the cohort. Further study is needed to confirm these race-ethnic differences and the reasons for them.Mira KatanYeseon P MoonMyunghee C PaikRobert L WolfertRalph L SaccoMitchell S V ElkindPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e83393 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mira Katan Yeseon P Moon Myunghee C Paik Robert L Wolfert Ralph L Sacco Mitchell S V Elkind Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.
description	<h4>Background</h4>Lipoprotein-associated phospholipase A2 (LpPLA2) levels are associated with stroke, though whether this extends to all populations and stroke subtypes is unknown.<h4>Methods</h4>Serum samples from stroke-free community participants in the Northern Manhattan Study were assayed for LpPLA2 mass and activity. Participants were followed annually for stroke. Cox-proportional-hazard models were fitted to estimate hazard-ratios and 95% confidence intervals (HR, 95% CI) for the association of LpPLA2 levels with ischemic stroke (IS), after adjusting for demographic and medical risk factors.<h4>Results</h4>Serum samples were available in 1946 participants, of whom 151 (7.8%) experienced a first IS during median follow-up 11 years. Mean age was 69 (SD 10), 35.6% were men, 20% non-Hispanic Whites, 22% non-Hispanic Blacks, and 55% Hispanics. LpPLA2 mass and activity levels were not associated with overall IS risk. LpPLA2 mass but not activity levels were associated with strokes due to large artery atherosclerosis (LAA; adjusted HR per SD 1.55, 95% CI 1.17-2.04). There was a dose-response relationship with LAA (compared to first quartile, 2nd quartile HR = 1.43, 95% CI 0.23-8.64; 3rd quartile HR = 4.47, 95% CI 0.93-21.54; 4th quartile HR = 5.07, 95% CI 1.07-24.06). The associations between LpPLA2-mass and LAA-stroke risk differed by race-ethnicity (p = 0.01); LpPLA2-mass was associated with increased risk of LAA among non-Hispanic Whites (adjusted HR per SD 1.44, 95% CI 0.98-2.11), but not other race-ethnic groups.<h4>Conclusion</h4>LpPLA2-mass levels were associated with risk of atherosclerotic stroke among non-Hispanic White participants, but not in other race-ethnic groups in the cohort. Further study is needed to confirm these race-ethnic differences and the reasons for them.
format	article
author	Mira Katan Yeseon P Moon Myunghee C Paik Robert L Wolfert Ralph L Sacco Mitchell S V Elkind
author_facet	Mira Katan Yeseon P Moon Myunghee C Paik Robert L Wolfert Ralph L Sacco Mitchell S V Elkind
author_sort	Mira Katan
title	Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.
title_short	Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.
title_full	Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.
title_fullStr	Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.
title_full_unstemmed	Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.
title_sort	lipoprotein-associated phospholipase a2 is associated with atherosclerotic stroke risk: the northern manhattan study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/9dc09fac60114a3698be6075e3f27a89
work_keys_str_mv	AT mirakatan lipoproteinassociatedphospholipasea2isassociatedwithatheroscleroticstrokeriskthenorthernmanhattanstudy AT yeseonpmoon lipoproteinassociatedphospholipasea2isassociatedwithatheroscleroticstrokeriskthenorthernmanhattanstudy AT myungheecpaik lipoproteinassociatedphospholipasea2isassociatedwithatheroscleroticstrokeriskthenorthernmanhattanstudy AT robertlwolfert lipoproteinassociatedphospholipasea2isassociatedwithatheroscleroticstrokeriskthenorthernmanhattanstudy AT ralphlsacco lipoproteinassociatedphospholipasea2isassociatedwithatheroscleroticstrokeriskthenorthernmanhattanstudy AT mitchellsvelkind lipoproteinassociatedphospholipasea2isassociatedwithatheroscleroticstrokeriskthenorthernmanhattanstudy
_version_	1718421517804503040

Lipoprotein-associated phospholipase A2 is associated with atherosclerotic stroke risk: the Northern Manhattan Study.

Ejemplares similares