Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities

Lung cancer is the second commonly diagnosed malignancy worldwide and has the highest mortality rate among all cancers. Tremendous efforts have been made to develop novel strategies against lung cancer; however, the overall survival of patients still is low. Uncovering underlying molecular mechanism...

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Autores principales:	Peyman Tabnak, Zanyar HajiEsmailPoor, Soroush Soraneh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lung cancer ferroptosis biomarkers cell death Nrf2 iron metabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9dc13c32e9c64a0cbccf84f98ceb8dbf
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spelling	oai:doaj.org-article:9dc13c32e9c64a0cbccf84f98ceb8dbf2021-12-02T09:59:19ZFerroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities2234-943X10.3389/fonc.2021.792827https://doaj.org/article/9dc13c32e9c64a0cbccf84f98ceb8dbf2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.792827/fullhttps://doaj.org/toc/2234-943XLung cancer is the second commonly diagnosed malignancy worldwide and has the highest mortality rate among all cancers. Tremendous efforts have been made to develop novel strategies against lung cancer; however, the overall survival of patients still is low. Uncovering underlying molecular mechanisms of this disease can open up new horizons for its treatment. Ferroptosis is a newly discovered type of programmed cell death that, in an iron-dependent manner, peroxidizes unsaturated phospholipids and results in the accumulation of radical oxygen species. Subsequent oxidative damage caused by ferroptosis contributes to cell death in tumor cells. Therefore, understanding its molecular mechanisms in lung cancer appears as a promising strategy to induce ferroptosis selectively. According to evidence published up to now, significant numbers of research have been done to identify ferroptosis regulators in lung cancer. Therefore, this review aims to provide a comprehensive standpoint of molecular mechanisms of ferroptosis in lung cancer and address these molecules’ prognostic and therapeutic values, hoping that the road for future studies in this field will be paved more efficiently.Peyman TabnakZanyar HajiEsmailPoorSoroush SoranehFrontiers Media S.A.articlelung cancerferroptosisbiomarkerscell deathNrf2iron metabolismNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer ferroptosis biomarkers cell death Nrf2 iron metabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lung cancer ferroptosis biomarkers cell death Nrf2 iron metabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Peyman Tabnak Zanyar HajiEsmailPoor Soroush Soraneh Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities
description	Lung cancer is the second commonly diagnosed malignancy worldwide and has the highest mortality rate among all cancers. Tremendous efforts have been made to develop novel strategies against lung cancer; however, the overall survival of patients still is low. Uncovering underlying molecular mechanisms of this disease can open up new horizons for its treatment. Ferroptosis is a newly discovered type of programmed cell death that, in an iron-dependent manner, peroxidizes unsaturated phospholipids and results in the accumulation of radical oxygen species. Subsequent oxidative damage caused by ferroptosis contributes to cell death in tumor cells. Therefore, understanding its molecular mechanisms in lung cancer appears as a promising strategy to induce ferroptosis selectively. According to evidence published up to now, significant numbers of research have been done to identify ferroptosis regulators in lung cancer. Therefore, this review aims to provide a comprehensive standpoint of molecular mechanisms of ferroptosis in lung cancer and address these molecules’ prognostic and therapeutic values, hoping that the road for future studies in this field will be paved more efficiently.
format	article
author	Peyman Tabnak Zanyar HajiEsmailPoor Soroush Soraneh
author_facet	Peyman Tabnak Zanyar HajiEsmailPoor Soroush Soraneh
author_sort	Peyman Tabnak
title	Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities
title_short	Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities
title_full	Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities
title_fullStr	Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities
title_full_unstemmed	Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities
title_sort	ferroptosis in lung cancer: from molecular mechanisms to prognostic and therapeutic opportunities
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9dc13c32e9c64a0cbccf84f98ceb8dbf
work_keys_str_mv	AT peymantabnak ferroptosisinlungcancerfrommolecularmechanismstoprognosticandtherapeuticopportunities AT zanyarhajiesmailpoor ferroptosisinlungcancerfrommolecularmechanismstoprognosticandtherapeuticopportunities AT soroushsoraneh ferroptosisinlungcancerfrommolecularmechanismstoprognosticandtherapeuticopportunities
_version_	1718397810257166336

Ferroptosis in Lung Cancer: From Molecular Mechanisms to Prognostic and Therapeutic Opportunities

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