Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular mechanism by which heme enhances processing fidelity.

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Autores principales:	Alexander C. Partin, Tri D. Ngo, Emily Herrell, Byung-Cheon Jeong, Gary Hon, Yunsun Nam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9dc320f8abfd4f8580b4b89fde13f51e
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spelling	oai:doaj.org-article:9dc320f8abfd4f8580b4b89fde13f51e2021-12-02T15:38:54ZHeme enables proper positioning of Drosha and DGCR8 on primary microRNAs10.1038/s41467-017-01713-y2041-1723https://doaj.org/article/9dc320f8abfd4f8580b4b89fde13f51e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01713-yhttps://doaj.org/toc/2041-1723Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular mechanism by which heme enhances processing fidelity.Alexander C. PartinTri D. NgoEmily HerrellByung-Cheon JeongGary HonYunsun NamNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander C. Partin Tri D. Ngo Emily Herrell Byung-Cheon Jeong Gary Hon Yunsun Nam Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
description	Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular mechanism by which heme enhances processing fidelity.
format	article
author	Alexander C. Partin Tri D. Ngo Emily Herrell Byung-Cheon Jeong Gary Hon Yunsun Nam
author_facet	Alexander C. Partin Tri D. Ngo Emily Herrell Byung-Cheon Jeong Gary Hon Yunsun Nam
author_sort	Alexander C. Partin
title	Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_short	Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_full	Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_fullStr	Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_full_unstemmed	Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
title_sort	heme enables proper positioning of drosha and dgcr8 on primary micrornas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9dc320f8abfd4f8580b4b89fde13f51e
work_keys_str_mv	AT alexandercpartin hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas AT tridngo hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas AT emilyherrell hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas AT byungcheonjeong hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas AT garyhon hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas AT yunsunnam hemeenablesproperpositioningofdroshaanddgcr8onprimarymicrornas
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Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

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