Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults

Keisuke Ueda,1,2 Hiroyuki Sasai,3 Takehiko Tsujimoto,4 Chiaki Sanbongi,1 Shuji Ikegami,1 Hiroyuki Kobayashi,5 Nobuhiko Shioya,6 Satoru Suzuki,7 Yoshio Nakata5 1Food Science and Technology Research Laboratories, Meiji Co., Ltd, Hachiouji, 2Graduate School of Comprehensive Human Sciences, University o...

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Autores principales:	Ueda K, Sasai H, Tsujimoto T, Sanbongi C, Ikegami S, Kobayashi H, Shioya N, Suzuki S, Nakata Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Amino acid supplementation physical activity promotion abdominal fat randomized controlled trial Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9dc49ddb24c74c76a77cab4f8694f9f4
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spelling	oai:doaj.org-article:9dc49ddb24c74c76a77cab4f8694f9f42021-12-02T05:19:57ZRandomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults1178-7007https://doaj.org/article/9dc49ddb24c74c76a77cab4f8694f9f42018-02-01T00:00:00Zhttps://www.dovepress.com/randomized-trial-of-amino-acid-mixture-combined-with-physical-activity-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Keisuke Ueda,1,2 Hiroyuki Sasai,3 Takehiko Tsujimoto,4 Chiaki Sanbongi,1 Shuji Ikegami,1 Hiroyuki Kobayashi,5 Nobuhiko Shioya,6 Satoru Suzuki,7 Yoshio Nakata5 1Food Science and Technology Research Laboratories, Meiji Co., Ltd, Hachiouji, 2Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 3Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, 4Faculty of Human Sciences, Shimane University, Matsue, 5Faculty of Medicine, University of Tsukuba, Tsukuba, 6KSO Corporation, Tokyo, 7Shinagawa Season Terrace Health Care Clinic, Tokyo, Japan Purpose: The purpose of this study was to test the efficacy of arginine, alanine, and phenylalanine mixture (A-mix) ingestion at 1,500 mg/day in combination with the promotion of physical activity for abdominal fat reduction in overweight adults.Methods: A placebo-controlled, double-blind, parallel-group, randomized trial for 12 weeks combined with a 4-week follow-up period was conducted at a single center in Minato-ku, Tokyo, Japan, between December 2016 and May 2017. Data were analyzed between June and August 2017. The study participants were 200 overweight adults within the age range of 20–64 years. The participants were randomly assigned to the A-mix group (n=100) or a placebo group (n=100) and were administered 500 mL of test beverage containing 1,500 or 0 mg of A-mix, respectively, for 12 weeks. All participants maintained a physically active lifestyle between week 0 and week 12 through monthly sessions of physical activity. The primary outcomes were the 12-week changes in the abdominal total, subcutaneous, and visceral fat areas, as assessed by computed tomography.Results: Of the 200 enrolled participants, 199 (99%) accomplished the 12-week intervention and 4-week follow-up period. The per-protocol-based analysis for 194 participants demonstrated that the abdominal total fat area decreased significantly in the A-mix group compared with that in the placebo group (difference, 10.0 cm2; 95% confidence interval [CI]: 0.4–19.6 cm2; P=0.041). Comparable outcomes were obtained for the abdominal subcutaneous fat area (difference, 7.4 cm2; 95% CI: 0.1–14.7 cm2; P=0.047). No study-related unfavorable events occurred.Conclusion: A-mix supplementation in combination with physical activity promotion facilitated abdominal fat reduction in overweight adults. Keywords: amino acid supplementation, physical activity promotion, abdominal fat, randomized controlled trialUeda KSasai HTsujimoto TSanbongi CIkegami SKobayashi HShioya NSuzuki SNakata YDove Medical PressarticleAmino acid supplementationphysical activity promotionabdominal fatrandomized controlled trialSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 23-33 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Amino acid supplementation physical activity promotion abdominal fat randomized controlled trial Specialties of internal medicine RC581-951
spellingShingle	Amino acid supplementation physical activity promotion abdominal fat randomized controlled trial Specialties of internal medicine RC581-951 Ueda K Sasai H Tsujimoto T Sanbongi C Ikegami S Kobayashi H Shioya N Suzuki S Nakata Y Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
description	Keisuke Ueda,1,2 Hiroyuki Sasai,3 Takehiko Tsujimoto,4 Chiaki Sanbongi,1 Shuji Ikegami,1 Hiroyuki Kobayashi,5 Nobuhiko Shioya,6 Satoru Suzuki,7 Yoshio Nakata5 1Food Science and Technology Research Laboratories, Meiji Co., Ltd, Hachiouji, 2Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 3Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, 4Faculty of Human Sciences, Shimane University, Matsue, 5Faculty of Medicine, University of Tsukuba, Tsukuba, 6KSO Corporation, Tokyo, 7Shinagawa Season Terrace Health Care Clinic, Tokyo, Japan Purpose: The purpose of this study was to test the efficacy of arginine, alanine, and phenylalanine mixture (A-mix) ingestion at 1,500 mg/day in combination with the promotion of physical activity for abdominal fat reduction in overweight adults.Methods: A placebo-controlled, double-blind, parallel-group, randomized trial for 12 weeks combined with a 4-week follow-up period was conducted at a single center in Minato-ku, Tokyo, Japan, between December 2016 and May 2017. Data were analyzed between June and August 2017. The study participants were 200 overweight adults within the age range of 20–64 years. The participants were randomly assigned to the A-mix group (n=100) or a placebo group (n=100) and were administered 500 mL of test beverage containing 1,500 or 0 mg of A-mix, respectively, for 12 weeks. All participants maintained a physically active lifestyle between week 0 and week 12 through monthly sessions of physical activity. The primary outcomes were the 12-week changes in the abdominal total, subcutaneous, and visceral fat areas, as assessed by computed tomography.Results: Of the 200 enrolled participants, 199 (99%) accomplished the 12-week intervention and 4-week follow-up period. The per-protocol-based analysis for 194 participants demonstrated that the abdominal total fat area decreased significantly in the A-mix group compared with that in the placebo group (difference, 10.0 cm2; 95% confidence interval [CI]: 0.4–19.6 cm2; P=0.041). Comparable outcomes were obtained for the abdominal subcutaneous fat area (difference, 7.4 cm2; 95% CI: 0.1–14.7 cm2; P=0.047). No study-related unfavorable events occurred.Conclusion: A-mix supplementation in combination with physical activity promotion facilitated abdominal fat reduction in overweight adults. Keywords: amino acid supplementation, physical activity promotion, abdominal fat, randomized controlled trial
format	article
author	Ueda K Sasai H Tsujimoto T Sanbongi C Ikegami S Kobayashi H Shioya N Suzuki S Nakata Y
author_facet	Ueda K Sasai H Tsujimoto T Sanbongi C Ikegami S Kobayashi H Shioya N Suzuki S Nakata Y
author_sort	Ueda K
title	Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
title_short	Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
title_full	Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
title_fullStr	Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
title_full_unstemmed	Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
title_sort	randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/9dc49ddb24c74c76a77cab4f8694f9f4
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Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults

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