IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS

In 46 patients with active pulmonary tuberculosis who were treated in 2014, the features of the immunological status by defining standard immunograms and serum levels of TNFα, IL-1β, IL-10, as well as autoantibodies to collagen I and III type have been studied. It was established that the hyperprodu...

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Autores principales:	L. G. Tarasova, E. N. Strel’tsova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2015
Materias:	tuberculosis tnfα il-1β il-10 type i collagen type iii collagen autoantibodies Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/9dc4fb60eb5f46b9b626f82946cf9ae0
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spelling	oai:doaj.org-article:9dc4fb60eb5f46b9b626f82946cf9ae02021-11-22T07:09:47ZIMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS2220-76192313-739810.15789/2220-7619-2015-1-85-88https://doaj.org/article/9dc4fb60eb5f46b9b626f82946cf9ae02015-04-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/278https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398In 46 patients with active pulmonary tuberculosis who were treated in 2014, the features of the immunological status by defining standard immunograms and serum levels of TNFα, IL-1β, IL-10, as well as autoantibodies to collagen I and III type have been studied. It was established that the hyperproduction of T lymphocytes mainly Th2 link (increased relative to the Trel content of 17.4% of the Tabs — 30.4%, IL-1β — 32.6%, IL-10 — 43.5%) arises because of the decrease in the phagocytic activity of the cells (ratio of active phagocytes 1.98±1.07 at a rate of 2.5–2.9; percentage phagocytosis 56.35±13.89% at a rate of 65–95%). The increase in the content of B-lymphocytes (Brel — 84.8%, in the Babs — 43.5%) and circulating immune complexes, in some cases combined with decreased levels of immunoglobulins G, A, M, believe, intended to compensate the negative impact of Mycobacterium tuberculosis the body of the patient. The larger the specific process, the more intense the metabolism of connective tissue, stimulates the formation of type-specific autoantibodies involved in the elimination of connective tissue components. Detecting increased levels of autoantibodies to collagen type I — 50% and type III — 26.1%, probably due to the fact that in the initial stage of development of pulmonary tuberculosis «pulmonary collagen» is involved in the pathological process is less than I type.L. G. TarasovaE. N. Strel’tsovaSankt-Peterburg : NIIÈM imeni Pasteraarticletuberculosistnfαil-1βil-10type i collagentype iii collagenautoantibodiesInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 5, Iss 1, Pp 85-88 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis tnfα il-1β il-10 type i collagen type iii collagen autoantibodies Infectious and parasitic diseases RC109-216
spellingShingle	tuberculosis tnfα il-1β il-10 type i collagen type iii collagen autoantibodies Infectious and parasitic diseases RC109-216 L. G. Tarasova E. N. Strel’tsova IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS
description	In 46 patients with active pulmonary tuberculosis who were treated in 2014, the features of the immunological status by defining standard immunograms and serum levels of TNFα, IL-1β, IL-10, as well as autoantibodies to collagen I and III type have been studied. It was established that the hyperproduction of T lymphocytes mainly Th2 link (increased relative to the Trel content of 17.4% of the Tabs — 30.4%, IL-1β — 32.6%, IL-10 — 43.5%) arises because of the decrease in the phagocytic activity of the cells (ratio of active phagocytes 1.98±1.07 at a rate of 2.5–2.9; percentage phagocytosis 56.35±13.89% at a rate of 65–95%). The increase in the content of B-lymphocytes (Brel — 84.8%, in the Babs — 43.5%) and circulating immune complexes, in some cases combined with decreased levels of immunoglobulins G, A, M, believe, intended to compensate the negative impact of Mycobacterium tuberculosis the body of the patient. The larger the specific process, the more intense the metabolism of connective tissue, stimulates the formation of type-specific autoantibodies involved in the elimination of connective tissue components. Detecting increased levels of autoantibodies to collagen type I — 50% and type III — 26.1%, probably due to the fact that in the initial stage of development of pulmonary tuberculosis «pulmonary collagen» is involved in the pathological process is less than I type.
format	article
author	L. G. Tarasova E. N. Strel’tsova
author_facet	L. G. Tarasova E. N. Strel’tsova
author_sort	L. G. Tarasova
title	IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS
title_short	IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS
title_full	IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS
title_fullStr	IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS
title_full_unstemmed	IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS
title_sort	immunological status of patients with tuberculosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2015
url	https://doaj.org/article/9dc4fb60eb5f46b9b626f82946cf9ae0
work_keys_str_mv	AT lgtarasova immunologicalstatusofpatientswithtuberculosis AT enstreltsova immunologicalstatusofpatientswithtuberculosis
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IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS

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