A novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment

A novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment

Xun Yuan,1,* Wenxiang Ji,2,* Si Chen,1 Yuling Bao,3 Songwei Tan,3 Shun Lu,2 Kongming Wu,1 Qian Chu11Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 2Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Ton...

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Autores principales: Yuan X, Ji W, Chen S, Bao Y, Tan S, Lu S, Wu K, Chu Q
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
poly(D
L-lactide-co-glycolide)
Tween 80
nanoparticle
drug resistance
lung cancer
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/9dc69c63c0d64c32967bc6c9d3a9965c
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spelling oai:doaj.org-article:9dc69c63c0d64c32967bc6c9d3a9965c2021-12-02T06:37:58ZA novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment1178-2013https://doaj.org/article/9dc69c63c0d64c32967bc6c9d3a9965c2016-05-01T00:00:00Zhttps://www.dovepress.com/a-novel-paclitaxel-loaded-polydl-lactide-co-glycolide-tween-80-copolym-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xun Yuan,1,* Wenxiang Ji,2,* Si Chen,1 Yuling Bao,3 Songwei Tan,3 Shun Lu,2 Kongming Wu,1 Qian Chu11Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 2Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 3School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workAbstract: Drug resistance has become a main obstacle for the effective treatment of lung cancer. To address this problem, a novel biocompatible nanoscale package, poly(D,L-lactide-co-glycolide)-Tween 80, was designed and synthesized to overcome paclitaxel (PTX) resistance in a PTX-resistant human lung cancer cell line. The poly(D,L-lactide-co-glycolide) (PLGA)-Tween 80 nanoparticles (NPs) could efficiently load PTX and release the drug gradually. There was an increased level of uptake of PLGA-Tween 80 in PTX-resistant lung cancer cell line A549/T, which achieved a significantly higher level of cytotoxicity than both PLGA NP formulation and Taxol®. The in vivo antitumor efficacy also showed that PLGA-Tween 80 NP was more effective than Taxol®, indicating that PLGA-Tween 80 copolymer was a promising carrier for PTX in resistant lung cancer. Keywords: poly(D,L-lactide-co-glycolide), Tween 80, nanoparticle, drug resistance, lung cancerYuan XJi WChen SBao YTan SLu SWu KChu QDove Medical Pressarticlepoly(DL-lactide-co-glycolide)Tween 80nanoparticledrug resistancelung cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2119-2131 (2016)
institution DOAJ
collection DOAJ
language EN
topic poly(D
L-lactide-co-glycolide)
Tween 80
nanoparticle
drug resistance
lung cancer
Medicine (General)
R5-920
spellingShingle poly(D
L-lactide-co-glycolide)
Tween 80
nanoparticle
drug resistance
lung cancer
Medicine (General)
R5-920
Yuan X
Ji W
Chen S
Bao Y
Tan S
Lu S
Wu K
Chu Q
A novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment
description Xun Yuan,1,* Wenxiang Ji,2,* Si Chen,1 Yuling Bao,3 Songwei Tan,3 Shun Lu,2 Kongming Wu,1 Qian Chu11Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 2Lung Tumor Clinical Medical Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 3School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workAbstract: Drug resistance has become a main obstacle for the effective treatment of lung cancer. To address this problem, a novel biocompatible nanoscale package, poly(D,L-lactide-co-glycolide)-Tween 80, was designed and synthesized to overcome paclitaxel (PTX) resistance in a PTX-resistant human lung cancer cell line. The poly(D,L-lactide-co-glycolide) (PLGA)-Tween 80 nanoparticles (NPs) could efficiently load PTX and release the drug gradually. There was an increased level of uptake of PLGA-Tween 80 in PTX-resistant lung cancer cell line A549/T, which achieved a significantly higher level of cytotoxicity than both PLGA NP formulation and Taxol®. The in vivo antitumor efficacy also showed that PLGA-Tween 80 NP was more effective than Taxol®, indicating that PLGA-Tween 80 copolymer was a promising carrier for PTX in resistant lung cancer. Keywords: poly(D,L-lactide-co-glycolide), Tween 80, nanoparticle, drug resistance, lung cancer
format article
author Yuan X
Ji W
Chen S
Bao Y
Tan S
Lu S
Wu K
Chu Q
author_facet Yuan X
Ji W
Chen S
Bao Y
Tan S
Lu S
Wu K
Chu Q
author_sort Yuan X
title A novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment
title_short A novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment
title_full A novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment
title_fullStr A novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment
title_full_unstemmed A novel paclitaxel-loaded poly(D,L-lactide-co-glycolide)-Tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment
title_sort novel paclitaxel-loaded poly(d,l-lactide-co-glycolide)-tween 80 copolymer nanoparticle overcoming multidrug resistance for lung cancer treatment
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/9dc69c63c0d64c32967bc6c9d3a9965c
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