The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma

Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methy...

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Autores principales: Zhe Li, Jiwei Zhang, Xinyang Liu, Shengli Li, Qifeng Wang, Di Chen, Zhixiang Hu, Tao Yu, Jie Ding, Jinjun Li, Ming Yao, Jia Fan, Shenglin Huang, Qiang Gao, Yingjun Zhao, Xianghuo He
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/9dcb8b8340b24598b29ef3aec8b84b0a
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spelling oai:doaj.org-article:9dcb8b8340b24598b29ef3aec8b84b0a2021-12-02T15:34:27ZThe LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma10.1038/s41467-018-04006-02041-1723https://doaj.org/article/9dcb8b8340b24598b29ef3aec8b84b0a2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04006-0https://doaj.org/toc/2041-1723Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP.Zhe LiJiwei ZhangXinyang LiuShengli LiQifeng WangDi ChenZhixiang HuTao YuJie DingJinjun LiMing YaoJia FanShenglin HuangQiang GaoYingjun ZhaoXianghuo HeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhe Li
Jiwei Zhang
Xinyang Liu
Shengli Li
Qifeng Wang
Di Chen
Zhixiang Hu
Tao Yu
Jie Ding
Jinjun Li
Ming Yao
Jia Fan
Shenglin Huang
Qiang Gao
Yingjun Zhao
Xianghuo He
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
description Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP.
format article
author Zhe Li
Jiwei Zhang
Xinyang Liu
Shengli Li
Qifeng Wang
Di Chen
Zhixiang Hu
Tao Yu
Jie Ding
Jinjun Li
Ming Yao
Jia Fan
Shenglin Huang
Qiang Gao
Yingjun Zhao
Xianghuo He
author_facet Zhe Li
Jiwei Zhang
Xinyang Liu
Shengli Li
Qifeng Wang
Di Chen
Zhixiang Hu
Tao Yu
Jie Ding
Jinjun Li
Ming Yao
Jia Fan
Shenglin Huang
Qiang Gao
Yingjun Zhao
Xianghuo He
author_sort Zhe Li
title The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_short The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_full The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_fullStr The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_full_unstemmed The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
title_sort linc01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/9dcb8b8340b24598b29ef3aec8b84b0a
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