Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy

Autonomic dysfunction is a feature of some α-synucleinopathies, but there are no models of pure autonomic dysfunction associated with α-synuclein. Here the authors describe a mouse model of pure autonomic dysfunction without motor dysfunciton by injection of pre-formed fibrils of α-synuclein to the...

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Autores principales:	Xue-Jing Wang, Ming-Ming Ma, Le-Bo Zhou, Xiao-Yi Jiang, Miao-Miao Hao, Robert K. F. Teng, Erxi Wu, Bei-Sha Tang, Jia-Yi Li, Jun-Fang Teng, Xue-Bing Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9dcb8eaff468400b9e806e46b8356181
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spelling	oai:doaj.org-article:9dcb8eaff468400b9e806e46b83561812021-12-02T14:41:13ZAutonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy10.1038/s41467-019-14189-92041-1723https://doaj.org/article/9dcb8eaff468400b9e806e46b83561812020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14189-9https://doaj.org/toc/2041-1723Autonomic dysfunction is a feature of some α-synucleinopathies, but there are no models of pure autonomic dysfunction associated with α-synuclein. Here the authors describe a mouse model of pure autonomic dysfunction without motor dysfunciton by injection of pre-formed fibrils of α-synuclein to the stellate and celiac ganglia.Xue-Jing WangMing-Ming MaLe-Bo ZhouXiao-Yi JiangMiao-Miao HaoRobert K. F. TengErxi WuBei-Sha TangJia-Yi LiJun-Fang TengXue-Bing DingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xue-Jing Wang Ming-Ming Ma Le-Bo Zhou Xiao-Yi Jiang Miao-Miao Hao Robert K. F. Teng Erxi Wu Bei-Sha Tang Jia-Yi Li Jun-Fang Teng Xue-Bing Ding Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
description	Autonomic dysfunction is a feature of some α-synucleinopathies, but there are no models of pure autonomic dysfunction associated with α-synuclein. Here the authors describe a mouse model of pure autonomic dysfunction without motor dysfunciton by injection of pre-formed fibrils of α-synuclein to the stellate and celiac ganglia.
format	article
author	Xue-Jing Wang Ming-Ming Ma Le-Bo Zhou Xiao-Yi Jiang Miao-Miao Hao Robert K. F. Teng Erxi Wu Bei-Sha Tang Jia-Yi Li Jun-Fang Teng Xue-Bing Ding
author_facet	Xue-Jing Wang Ming-Ming Ma Le-Bo Zhou Xiao-Yi Jiang Miao-Miao Hao Robert K. F. Teng Erxi Wu Bei-Sha Tang Jia-Yi Li Jun-Fang Teng Xue-Bing Ding
author_sort	Xue-Jing Wang
title	Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
title_short	Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
title_full	Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
title_fullStr	Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
title_full_unstemmed	Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
title_sort	autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9dcb8eaff468400b9e806e46b8356181
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Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy

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