Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes

Abstract Visceral adiposity index (VAI) is a novel sex-specific index for visceral adipose function; however the association between VAI and hyperuricemia in China is unknown. We aimed to investigate this association, also whether it was independent of metabolic health and obesity phenotypes. 7632 a...

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Autores principales:	Huimin Dong, Yang Xu, Xiuzhi Zhang, Simiao Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9dcd149c5b7845f6b3624d4db7be5627
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spelling	oai:doaj.org-article:9dcd149c5b7845f6b3624d4db7be56272021-12-02T11:52:31ZVisceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes10.1038/s41598-017-09455-z2045-2322https://doaj.org/article/9dcd149c5b7845f6b3624d4db7be56272017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09455-zhttps://doaj.org/toc/2045-2322Abstract Visceral adiposity index (VAI) is a novel sex-specific index for visceral adipose function; however the association between VAI and hyperuricemia in China is unknown. We aimed to investigate this association, also whether it was independent of metabolic health and obesity phenotypes. 7632 adult subjects from the China Health and Nutrition Survey 2009 were retained. Subjects were categorized into four obesity phenotypes based on a cross-classification of BMI and metabolic health status by two representative criteria. VAI was the best predictors for hyperuricemia irrespective of obesity phenotypes, with area under curve (AUC) ranging 0.665–0.719. The odd ratio (OR) for hyperuricemia in the highest quartile of the VAI were 6.93 (95% CI 5.79–8.29) after adjusting for age and gender. Following further adjustments for metabolic obesity phenotypes and lifestyle confounders, the ORs were 4.88 (3.92–6.09) and 5.65 (4.68–6.82) according to these two criteria, respectively. A similar significant pattern was still found even after adjustment for blood pressure and other cardiovascular risks. Within each metabolic obesity phenotype, the significant association between VAI and hyperuricemia was consistently evident. In conclusion, the association of the VAI with hyperuricemia was significant, especially this association was independent of metabolic health and obesity phenotypes in the Chinese population.Huimin DongYang XuXiuzhi ZhangSimiao TianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huimin Dong Yang Xu Xiuzhi Zhang Simiao Tian Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes
description	Abstract Visceral adiposity index (VAI) is a novel sex-specific index for visceral adipose function; however the association between VAI and hyperuricemia in China is unknown. We aimed to investigate this association, also whether it was independent of metabolic health and obesity phenotypes. 7632 adult subjects from the China Health and Nutrition Survey 2009 were retained. Subjects were categorized into four obesity phenotypes based on a cross-classification of BMI and metabolic health status by two representative criteria. VAI was the best predictors for hyperuricemia irrespective of obesity phenotypes, with area under curve (AUC) ranging 0.665–0.719. The odd ratio (OR) for hyperuricemia in the highest quartile of the VAI were 6.93 (95% CI 5.79–8.29) after adjusting for age and gender. Following further adjustments for metabolic obesity phenotypes and lifestyle confounders, the ORs were 4.88 (3.92–6.09) and 5.65 (4.68–6.82) according to these two criteria, respectively. A similar significant pattern was still found even after adjustment for blood pressure and other cardiovascular risks. Within each metabolic obesity phenotype, the significant association between VAI and hyperuricemia was consistently evident. In conclusion, the association of the VAI with hyperuricemia was significant, especially this association was independent of metabolic health and obesity phenotypes in the Chinese population.
format	article
author	Huimin Dong Yang Xu Xiuzhi Zhang Simiao Tian
author_facet	Huimin Dong Yang Xu Xiuzhi Zhang Simiao Tian
author_sort	Huimin Dong
title	Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes
title_short	Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes
title_full	Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes
title_fullStr	Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes
title_full_unstemmed	Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes
title_sort	visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9dcd149c5b7845f6b3624d4db7be5627
work_keys_str_mv	AT huimindong visceraladiposityindexisstronglyassociatedwithhyperuricemiaindependentlyofmetabolichealthandobesityphenotypes AT yangxu visceraladiposityindexisstronglyassociatedwithhyperuricemiaindependentlyofmetabolichealthandobesityphenotypes AT xiuzhizhang visceraladiposityindexisstronglyassociatedwithhyperuricemiaindependentlyofmetabolichealthandobesityphenotypes AT simiaotian visceraladiposityindexisstronglyassociatedwithhyperuricemiaindependentlyofmetabolichealthandobesityphenotypes
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Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes

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