Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C

Introduction and objectives: Cause of mortality in patients with chronic liver diseases (CLDs) may differ based on underlying etiology of liver disease. Our aim was to assess different causes of death in patients with the most common types of CLD using a national database from the United States.Mate...

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Autores principales:	Pegah Golabi, James M. Paik, Katherine Eberly, Leyla de Avila, Saleh A. Alqahtani, Zobair M. Younossi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Outcome Trend Cirrhosis Non-alcoholic fatty liver disease Alcoholic liver disease Chronic hepatitis B Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9dd351b1e3df4b9984a76091ab5c273b
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spelling	oai:doaj.org-article:9dd351b1e3df4b9984a76091ab5c273b2021-11-30T04:14:43ZCauses of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C1665-268110.1016/j.aohep.2021.100556https://doaj.org/article/9dd351b1e3df4b9984a76091ab5c273b2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1665268121002556https://doaj.org/toc/1665-2681Introduction and objectives: Cause of mortality in patients with chronic liver diseases (CLDs) may differ based on underlying etiology of liver disease. Our aim was to assess different causes of death in patients with the most common types of CLD using a national database from the United States.Materials and methods: Death data from 2008 and 2018 from the National Vital Statistics System (NVSS) by the National Center for Health Statistics (NCHS) were used. The rank of cause-of-death for each etiology of CLDs was assessed. Causes of death were classified by the ICD-10 codes. Liver-related deaths included liver cancer, cirrhosis and CLDs.Results: Among a total of 2,826,531 deaths in 2018, there were 85,807 (3.04%) with underlying CLD (mean age at death 63.0 years, 63.8% male, 70.8% white). Liver-related mortality was the leading cause of death for all types of CLD [45.8% in non-alcoholic fatty liver disease (NAFLD), 53.0% in chronic hepatitis C (CHC), 57.8% in chronic hepatitis B (CHB), 81.8% in alcoholic liver disease (ALD)]. This was followed by death from cardiac causes (NAFLD 10.3%, CHC 9.1%, CHB 4.6%, ALD 4.2%) and extrahepatic cancer (NAFLD 7.0%, CHC 11.9%, CHB 14.9%, ALD 2.1%). Although liver cancer was the leading cause of cancer death, lung, colorectal and pancreatic cancer were also common causes of cancer death.Conclusions: Among deceased patients with CLD, underlying liver disease was the leading cause of death. Among solid cancers, liver cancer was the leading cause of cancer-related mortality.Pegah GolabiJames M. PaikKatherine EberlyLeyla de AvilaSaleh A. AlqahtaniZobair M. YounossiElsevierarticleOutcomeTrendCirrhosisNon-alcoholic fatty liver diseaseAlcoholic liver diseaseChronic hepatitis BSpecialties of internal medicineRC581-951ENAnnals of Hepatology, Vol 27, Iss 1, Pp 100556- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Outcome Trend Cirrhosis Non-alcoholic fatty liver disease Alcoholic liver disease Chronic hepatitis B Specialties of internal medicine RC581-951
spellingShingle	Outcome Trend Cirrhosis Non-alcoholic fatty liver disease Alcoholic liver disease Chronic hepatitis B Specialties of internal medicine RC581-951 Pegah Golabi James M. Paik Katherine Eberly Leyla de Avila Saleh A. Alqahtani Zobair M. Younossi Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C
description	Introduction and objectives: Cause of mortality in patients with chronic liver diseases (CLDs) may differ based on underlying etiology of liver disease. Our aim was to assess different causes of death in patients with the most common types of CLD using a national database from the United States.Materials and methods: Death data from 2008 and 2018 from the National Vital Statistics System (NVSS) by the National Center for Health Statistics (NCHS) were used. The rank of cause-of-death for each etiology of CLDs was assessed. Causes of death were classified by the ICD-10 codes. Liver-related deaths included liver cancer, cirrhosis and CLDs.Results: Among a total of 2,826,531 deaths in 2018, there were 85,807 (3.04%) with underlying CLD (mean age at death 63.0 years, 63.8% male, 70.8% white). Liver-related mortality was the leading cause of death for all types of CLD [45.8% in non-alcoholic fatty liver disease (NAFLD), 53.0% in chronic hepatitis C (CHC), 57.8% in chronic hepatitis B (CHB), 81.8% in alcoholic liver disease (ALD)]. This was followed by death from cardiac causes (NAFLD 10.3%, CHC 9.1%, CHB 4.6%, ALD 4.2%) and extrahepatic cancer (NAFLD 7.0%, CHC 11.9%, CHB 14.9%, ALD 2.1%). Although liver cancer was the leading cause of cancer death, lung, colorectal and pancreatic cancer were also common causes of cancer death.Conclusions: Among deceased patients with CLD, underlying liver disease was the leading cause of death. Among solid cancers, liver cancer was the leading cause of cancer-related mortality.
format	article
author	Pegah Golabi James M. Paik Katherine Eberly Leyla de Avila Saleh A. Alqahtani Zobair M. Younossi
author_facet	Pegah Golabi James M. Paik Katherine Eberly Leyla de Avila Saleh A. Alqahtani Zobair M. Younossi
author_sort	Pegah Golabi
title	Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C
title_short	Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C
title_full	Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C
title_fullStr	Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C
title_full_unstemmed	Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C
title_sort	causes of death in patients with non-alcoholic fatty liver disease (nafld), alcoholic liver disease and chronic viral hepatitis b and c
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/9dd351b1e3df4b9984a76091ab5c273b
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Causes of death in patients with Non-alcoholic Fatty Liver Disease (NAFLD), alcoholic liver disease and chronic viral Hepatitis B and C

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