Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival

Data mining of a public transcriptomic rectal cancer dataset (GSE35452) from the Gene Expression Omnibus, National Center for Biotechnology Information identified the melanophilin (<i>MLPH</i>) gene as the most significant intracellular protein transport-related gene (GO:0006886) associa...

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Autores principales:	Wan-Shan Li, Chih-I Chen, Hsin-Pao Chen, Kuang-Wen Liu, Chia-Jen Tsai, Ching-Chieh Yang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	melanophilin rectal cancer chemoradiotherapy response survival Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9dd618207bd8439f87ff50e0392e6461
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spelling	oai:doaj.org-article:9dd618207bd8439f87ff50e0392e64612021-11-25T17:21:53ZOverexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival10.3390/diagnostics111121322075-4418https://doaj.org/article/9dd618207bd8439f87ff50e0392e64612021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2132https://doaj.org/toc/2075-4418Data mining of a public transcriptomic rectal cancer dataset (GSE35452) from the Gene Expression Omnibus, National Center for Biotechnology Information identified the melanophilin (<i>MLPH</i>) gene as the most significant intracellular protein transport-related gene (GO:0006886) associated with a poor response to preoperative chemoradiation. An MLPH immunostain was performed on biopsy specimens from 172 rectal cancer patients receiving preoperative chemoradiation; samples were divided into high- and low-expression groups by H-scores. Subsequently, the correlations between MLPH expression and clinicopathologic features, tumor regression grade, disease-specific survival (DSS), local recurrence-free survival (LRFS), and metastasis-free survival (MeFS) were analyzed. MLPH expression was significantly associated with CEA level (<i>p</i> = 0.001), pre-treatment tumor status (<i>p</i> = 0.022), post-treatment tumor status (<i>p</i> < 0.001), post-treatment nodal status (<i>p</i> < 0.001), vascular invasion (<i>p</i> = 0.028), and tumor regression grade (<i>p</i> < 0.001). After uni- and multi-variable analysis of five-year survival, MLPH expression was still associated with lower DSS (hazard ratio (HR), 10.110; 95% confidence interval (CI), 2.178–46.920; <i>p</i> = 0.003) and MeFS (HR, 5.621; 95% CI, 1.762–17.931; <i>p</i> = 0.004). In conclusion, identifying MLPH expression could help to predict the response to chemoradiation and survival, and aid in personal therapeutic modification.Wan-Shan LiChih-I ChenHsin-Pao ChenKuang-Wen LiuChia-Jen TsaiChing-Chieh YangMDPI AGarticlemelanophilinrectal cancerchemoradiotherapyresponsesurvivalMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2132, p 2132 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	melanophilin rectal cancer chemoradiotherapy response survival Medicine (General) R5-920
spellingShingle	melanophilin rectal cancer chemoradiotherapy response survival Medicine (General) R5-920 Wan-Shan Li Chih-I Chen Hsin-Pao Chen Kuang-Wen Liu Chia-Jen Tsai Ching-Chieh Yang Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival
description	Data mining of a public transcriptomic rectal cancer dataset (GSE35452) from the Gene Expression Omnibus, National Center for Biotechnology Information identified the melanophilin (<i>MLPH</i>) gene as the most significant intracellular protein transport-related gene (GO:0006886) associated with a poor response to preoperative chemoradiation. An MLPH immunostain was performed on biopsy specimens from 172 rectal cancer patients receiving preoperative chemoradiation; samples were divided into high- and low-expression groups by H-scores. Subsequently, the correlations between MLPH expression and clinicopathologic features, tumor regression grade, disease-specific survival (DSS), local recurrence-free survival (LRFS), and metastasis-free survival (MeFS) were analyzed. MLPH expression was significantly associated with CEA level (<i>p</i> = 0.001), pre-treatment tumor status (<i>p</i> = 0.022), post-treatment tumor status (<i>p</i> < 0.001), post-treatment nodal status (<i>p</i> < 0.001), vascular invasion (<i>p</i> = 0.028), and tumor regression grade (<i>p</i> < 0.001). After uni- and multi-variable analysis of five-year survival, MLPH expression was still associated with lower DSS (hazard ratio (HR), 10.110; 95% confidence interval (CI), 2.178–46.920; <i>p</i> = 0.003) and MeFS (HR, 5.621; 95% CI, 1.762–17.931; <i>p</i> = 0.004). In conclusion, identifying MLPH expression could help to predict the response to chemoradiation and survival, and aid in personal therapeutic modification.
format	article
author	Wan-Shan Li Chih-I Chen Hsin-Pao Chen Kuang-Wen Liu Chia-Jen Tsai Ching-Chieh Yang
author_facet	Wan-Shan Li Chih-I Chen Hsin-Pao Chen Kuang-Wen Liu Chia-Jen Tsai Ching-Chieh Yang
author_sort	Wan-Shan Li
title	Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival
title_short	Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival
title_full	Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival
title_fullStr	Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival
title_full_unstemmed	Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival
title_sort	overexpression of mlph in rectal cancer patients correlates with a poorer response to preoperative chemoradiotherapy and reduced patient survival
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9dd618207bd8439f87ff50e0392e6461
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Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival

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