Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.

<h4>Unlabelled</h4>Worldwide, paracetamol is administered as a remedy for complaints that occur after vaccination. Recently published results indicate that paracetamol inhibits the vaccination response in infants when given prior to vaccination. The goal of this study was to establish wh...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anne M C M Doedée, Greet J Boland, Jeroen L A Pennings, Arja de Klerk, Guy A M Berbers, Fiona R M van der Klis, Hester E de Melker, Henk van Loveren, Riny Janssen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9dd66319163a4a6ba0e737ccf316a2dc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9dd66319163a4a6ba0e737ccf316a2dc
record_format	dspace
spelling	oai:doaj.org-article:9dd66319163a4a6ba0e737ccf316a2dc2021-11-18T08:17:06ZEffects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.1932-620310.1371/journal.pone.0098175https://doaj.org/article/9dd66319163a4a6ba0e737ccf316a2dc2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24897504/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Worldwide, paracetamol is administered as a remedy for complaints that occur after vaccination. Recently published results indicate that paracetamol inhibits the vaccination response in infants when given prior to vaccination. The goal of this study was to establish whether paracetamol exerts similar effects in young adults. In addition, the effect of timing of paracetamol intake was investigated. In two randomized, controlled, open-label studies 496 healthy young adults were randomly assigned to three groups. The study groups received paracetamol for 24 hours starting at the time of (prophylactic use) - or 6 hours after (therapeutic use) the primary (0 month) and first booster (1 month) hepatitis B vaccination. The control group received no paracetamol. None of the participants used paracetamol around the second booster (6 months) vaccination. Anti-HBs levels were measured prior to and one month after the second booster vaccination on ADVIA Centaur XP. One month after the second booster vaccination, the anti-HBs level in the prophylactic paracetamol group was significantly lower (p = 0.048) than the level in the control group (4257 mIU/mL vs. 5768 mIU/mL). The anti-HBs level in the therapeutic paracetamol group (4958 mIU/mL) was not different (p = 0.34) from the level in the control group. Only prophylactic paracetamol treatment, and not therapeutic treatment, during vaccination has a negative influence on the antibody concentration after hepatitis B vaccination in adults. These findings prompt to consider therapeutic instead of prophylactic treatment to ensure maximal vaccination efficacy and retain the possibility to treat pain and fever after vaccination.<h4>Trial registration</h4>Controlled-Trials.com ISRCTN03576945.Anne M C M DoedéeGreet J BolandJeroen L A PenningsArja de KlerkGuy A M BerbersFiona R M van der KlisHester E de MelkerHenk van LoverenRiny JanssenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98175 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne M C M Doedée Greet J Boland Jeroen L A Pennings Arja de Klerk Guy A M Berbers Fiona R M van der Klis Hester E de Melker Henk van Loveren Riny Janssen Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.
description	<h4>Unlabelled</h4>Worldwide, paracetamol is administered as a remedy for complaints that occur after vaccination. Recently published results indicate that paracetamol inhibits the vaccination response in infants when given prior to vaccination. The goal of this study was to establish whether paracetamol exerts similar effects in young adults. In addition, the effect of timing of paracetamol intake was investigated. In two randomized, controlled, open-label studies 496 healthy young adults were randomly assigned to three groups. The study groups received paracetamol for 24 hours starting at the time of (prophylactic use) - or 6 hours after (therapeutic use) the primary (0 month) and first booster (1 month) hepatitis B vaccination. The control group received no paracetamol. None of the participants used paracetamol around the second booster (6 months) vaccination. Anti-HBs levels were measured prior to and one month after the second booster vaccination on ADVIA Centaur XP. One month after the second booster vaccination, the anti-HBs level in the prophylactic paracetamol group was significantly lower (p = 0.048) than the level in the control group (4257 mIU/mL vs. 5768 mIU/mL). The anti-HBs level in the therapeutic paracetamol group (4958 mIU/mL) was not different (p = 0.34) from the level in the control group. Only prophylactic paracetamol treatment, and not therapeutic treatment, during vaccination has a negative influence on the antibody concentration after hepatitis B vaccination in adults. These findings prompt to consider therapeutic instead of prophylactic treatment to ensure maximal vaccination efficacy and retain the possibility to treat pain and fever after vaccination.<h4>Trial registration</h4>Controlled-Trials.com ISRCTN03576945.
format	article
author	Anne M C M Doedée Greet J Boland Jeroen L A Pennings Arja de Klerk Guy A M Berbers Fiona R M van der Klis Hester E de Melker Henk van Loveren Riny Janssen
author_facet	Anne M C M Doedée Greet J Boland Jeroen L A Pennings Arja de Klerk Guy A M Berbers Fiona R M van der Klis Hester E de Melker Henk van Loveren Riny Janssen
author_sort	Anne M C M Doedée
title	Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.
title_short	Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.
title_full	Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.
title_fullStr	Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.
title_full_unstemmed	Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.
title_sort	effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis b antibody levels in adults: two open-label, randomized controlled trials.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/9dd66319163a4a6ba0e737ccf316a2dc
work_keys_str_mv	AT annemcmdoedee effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials AT greetjboland effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials AT jeroenlapennings effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials AT arjadeklerk effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials AT guyamberbers effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials AT fionarmvanderklis effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials AT hesteredemelker effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials AT henkvanloveren effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials AT rinyjanssen effectsofprophylacticandtherapeuticparacetamoltreatmentduringvaccinationonhepatitisbantibodylevelsinadultstwoopenlabelrandomizedcontrolledtrials
_version_	1718422000573087744

Effects of prophylactic and therapeutic paracetamol treatment during vaccination on hepatitis B antibody levels in adults: two open-label, randomized controlled trials.

Ejemplares similares