Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation
Summary: Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate tha...
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Elsevier
2021
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oai:doaj.org-article:9ddeea64d4aa4a58a9dc1826671410922021-11-04T04:29:35ZMonoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation2211-124710.1016/j.celrep.2021.109942https://doaj.org/article/9ddeea64d4aa4a58a9dc1826671410922021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211124721014157https://doaj.org/toc/2211-1247Summary: Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate that prophylactic mAb treatment blocks viral replication in both the upper and lower respiratory tracts in aged, type 2 diabetic rhesus macaques. mAb infusion dramatically curtails severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated stimulation of interferon-induced chemokines and T cell activation, significantly reducing development of interstitial pneumonia. Furthermore, mAb infusion significantly dampens the greater than 3-fold increase in SARS-CoV-2-induced effector CD4 T cell influx into the cerebrospinal fluid. Our data show that neutralizing mAbs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.Anil VermaChase E. HawesYashavanth Shaan LakshmanappaJamin W. RohBrian A. SchmidtJoseph DutraWilliam LouieHongwei LiuZhong-Min MaJennifer K. WatanabeJodie L. UsachenkoRamya ImmareddyRebecca L. SammakRachel PollardJ. Rachel ReaderKatherine J. OlstadLark L. CoffeyPamela A. KozlowskiDennis J. Hartigan-O’ConnorMichel NussenzweigKoen K.A. Van RompayJohn H. MorrisonSmita S. IyerElsevierarticleneuroinflammationeffector CD4 T cellsrhesus macaquesSARS-CoV-2NeuroCOVID, inflammationcerebrospinal fluidBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109942- (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
neuroinflammation effector CD4 T cells rhesus macaques SARS-CoV-2 NeuroCOVID, inflammation cerebrospinal fluid Biology (General) QH301-705.5 |
| spellingShingle |
neuroinflammation effector CD4 T cells rhesus macaques SARS-CoV-2 NeuroCOVID, inflammation cerebrospinal fluid Biology (General) QH301-705.5 Anil Verma Chase E. Hawes Yashavanth Shaan Lakshmanappa Jamin W. Roh Brian A. Schmidt Joseph Dutra William Louie Hongwei Liu Zhong-Min Ma Jennifer K. Watanabe Jodie L. Usachenko Ramya Immareddy Rebecca L. Sammak Rachel Pollard J. Rachel Reader Katherine J. Olstad Lark L. Coffey Pamela A. Kozlowski Dennis J. Hartigan-O’Connor Michel Nussenzweig Koen K.A. Van Rompay John H. Morrison Smita S. Iyer Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation |
| description |
Summary: Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate that prophylactic mAb treatment blocks viral replication in both the upper and lower respiratory tracts in aged, type 2 diabetic rhesus macaques. mAb infusion dramatically curtails severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated stimulation of interferon-induced chemokines and T cell activation, significantly reducing development of interstitial pneumonia. Furthermore, mAb infusion significantly dampens the greater than 3-fold increase in SARS-CoV-2-induced effector CD4 T cell influx into the cerebrospinal fluid. Our data show that neutralizing mAbs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure. |
| format |
article |
| author |
Anil Verma Chase E. Hawes Yashavanth Shaan Lakshmanappa Jamin W. Roh Brian A. Schmidt Joseph Dutra William Louie Hongwei Liu Zhong-Min Ma Jennifer K. Watanabe Jodie L. Usachenko Ramya Immareddy Rebecca L. Sammak Rachel Pollard J. Rachel Reader Katherine J. Olstad Lark L. Coffey Pamela A. Kozlowski Dennis J. Hartigan-O’Connor Michel Nussenzweig Koen K.A. Van Rompay John H. Morrison Smita S. Iyer |
| author_facet |
Anil Verma Chase E. Hawes Yashavanth Shaan Lakshmanappa Jamin W. Roh Brian A. Schmidt Joseph Dutra William Louie Hongwei Liu Zhong-Min Ma Jennifer K. Watanabe Jodie L. Usachenko Ramya Immareddy Rebecca L. Sammak Rachel Pollard J. Rachel Reader Katherine J. Olstad Lark L. Coffey Pamela A. Kozlowski Dennis J. Hartigan-O’Connor Michel Nussenzweig Koen K.A. Van Rompay John H. Morrison Smita S. Iyer |
| author_sort |
Anil Verma |
| title |
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation |
| title_short |
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation |
| title_full |
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation |
| title_fullStr |
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation |
| title_full_unstemmed |
Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation |
| title_sort |
monoclonal antibodies protect aged rhesus macaques from sars-cov-2-induced immune activation and neuroinflammation |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/9ddeea64d4aa4a58a9dc182667141092 |
| work_keys_str_mv |
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