Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation

Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation

Summary: Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate tha...

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Auteurs principaux: Anil Verma, Chase E. Hawes, Yashavanth Shaan Lakshmanappa, Jamin W. Roh, Brian A. Schmidt, Joseph Dutra, William Louie, Hongwei Liu, Zhong-Min Ma, Jennifer K. Watanabe, Jodie L. Usachenko, Ramya Immareddy, Rebecca L. Sammak, Rachel Pollard, J. Rachel Reader, Katherine J. Olstad, Lark L. Coffey, Pamela A. Kozlowski, Dennis J. Hartigan-O’Connor, Michel Nussenzweig, Koen K.A. Van Rompay, John H. Morrison, Smita S. Iyer
Format: article
Langue:EN
Publié: Elsevier 2021
Sujets:
neuroinflammation
effector CD4 T cells
rhesus macaques
SARS-CoV-2
NeuroCOVID, inflammation
cerebrospinal fluid
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/9ddeea64d4aa4a58a9dc182667141092
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https://doaj.org/article/9ddeea64d4aa4a58a9dc182667141092

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