Nitric Oxide regulates mouth development in amphioxus

Abstract The development of the mouth in animals has fascinated researchers for decades, and a recent study proposed the modern view of recurrent evolution of protostomy and deuterostomy. Here we expanded our knowledge about conserved traits of mouth formation in chordates, testing the hypothesis th...

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Autores principales:	Giovanni Annona, Filomena Caccavale, Juan Pascual-Anaya, Shigeru Kuratani, Pasquale De Luca, Anna Palumbo, Salvatore D’Aniello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9de11b66dcdc4b5ebca123017304a261
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spelling	oai:doaj.org-article:9de11b66dcdc4b5ebca123017304a2612021-12-02T11:40:43ZNitric Oxide regulates mouth development in amphioxus10.1038/s41598-017-08157-w2045-2322https://doaj.org/article/9de11b66dcdc4b5ebca123017304a2612017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08157-whttps://doaj.org/toc/2045-2322Abstract The development of the mouth in animals has fascinated researchers for decades, and a recent study proposed the modern view of recurrent evolution of protostomy and deuterostomy. Here we expanded our knowledge about conserved traits of mouth formation in chordates, testing the hypothesis that nitric oxide (NO) is a potential regulator of this process. In the present work we show for the first time that NO is an essential cell signaling molecule for cephalochordate mouth formation, as previously shown for vertebrates, indicating its conserved ancestral role in chordates. The experimental decrease of NO during early amphioxus Branchiostoma lanceolatum development impaired the formation of the mouth and gill slits, demonstrating that it is a prerequisite in pharyngeal morphogenesis. Our results represent the first step in the understanding of NO physiology in non-vertebrate chordates, opening new evolutionary perspectives into the ancestral importance of NO homeostasis and acquisition of novel biological roles during evolution.Giovanni AnnonaFilomena CaccavaleJuan Pascual-AnayaShigeru KurataniPasquale De LucaAnna PalumboSalvatore D’AnielloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giovanni Annona Filomena Caccavale Juan Pascual-Anaya Shigeru Kuratani Pasquale De Luca Anna Palumbo Salvatore D’Aniello Nitric Oxide regulates mouth development in amphioxus
description	Abstract The development of the mouth in animals has fascinated researchers for decades, and a recent study proposed the modern view of recurrent evolution of protostomy and deuterostomy. Here we expanded our knowledge about conserved traits of mouth formation in chordates, testing the hypothesis that nitric oxide (NO) is a potential regulator of this process. In the present work we show for the first time that NO is an essential cell signaling molecule for cephalochordate mouth formation, as previously shown for vertebrates, indicating its conserved ancestral role in chordates. The experimental decrease of NO during early amphioxus Branchiostoma lanceolatum development impaired the formation of the mouth and gill slits, demonstrating that it is a prerequisite in pharyngeal morphogenesis. Our results represent the first step in the understanding of NO physiology in non-vertebrate chordates, opening new evolutionary perspectives into the ancestral importance of NO homeostasis and acquisition of novel biological roles during evolution.
format	article
author	Giovanni Annona Filomena Caccavale Juan Pascual-Anaya Shigeru Kuratani Pasquale De Luca Anna Palumbo Salvatore D’Aniello
author_facet	Giovanni Annona Filomena Caccavale Juan Pascual-Anaya Shigeru Kuratani Pasquale De Luca Anna Palumbo Salvatore D’Aniello
author_sort	Giovanni Annona
title	Nitric Oxide regulates mouth development in amphioxus
title_short	Nitric Oxide regulates mouth development in amphioxus
title_full	Nitric Oxide regulates mouth development in amphioxus
title_fullStr	Nitric Oxide regulates mouth development in amphioxus
title_full_unstemmed	Nitric Oxide regulates mouth development in amphioxus
title_sort	nitric oxide regulates mouth development in amphioxus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9de11b66dcdc4b5ebca123017304a261
work_keys_str_mv	AT giovanniannona nitricoxideregulatesmouthdevelopmentinamphioxus AT filomenacaccavale nitricoxideregulatesmouthdevelopmentinamphioxus AT juanpascualanaya nitricoxideregulatesmouthdevelopmentinamphioxus AT shigerukuratani nitricoxideregulatesmouthdevelopmentinamphioxus AT pasqualedeluca nitricoxideregulatesmouthdevelopmentinamphioxus AT annapalumbo nitricoxideregulatesmouthdevelopmentinamphioxus AT salvatoredaniello nitricoxideregulatesmouthdevelopmentinamphioxus
_version_	1718395597501759488

Nitric Oxide regulates mouth development in amphioxus

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