Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking

Proteins are transported among eukaryotic organelles along the cytoskeleton in membrane carriers. Here authors find that the Dopey1-Mon2 complex functions as a dual-lipid-regulated cargo-adaptor to recruit kinesin-1 to secretory and endocytic organelles or membrane carriers.

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Detalles Bibliográficos
Autores principales: Divyanshu Mahajan, Hieng Chiong Tie, Bing Chen, Lei Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9de2233012aa4d588501ab76385c1065
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Descripción
Sumario:Proteins are transported among eukaryotic organelles along the cytoskeleton in membrane carriers. Here authors find that the Dopey1-Mon2 complex functions as a dual-lipid-regulated cargo-adaptor to recruit kinesin-1 to secretory and endocytic organelles or membrane carriers.