Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study

ObjectivesThere are still challenging problems in diagnosis of hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) before operation. This study aimed to analyze the imaging features of HCC with B1–B3 BDTT.Materials and MethodsThe clinicopathological data and imaging findings of 30 HC...

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Autores principales:	Jun-Yi Wu, Li-Ming Huang, Yan-Nan Bai, Jia-Yi Wu, Yong-Gang Wei, Zhi-Bo Zhang, Mao-Lin Yan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hepatocellular carcinoma bile duct tumor thrombus computed tomography magnetic resonance imaging intrahepatic bile duct dilation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9de406bb1f43471a8436617e3e48ae00
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spelling	oai:doaj.org-article:9de406bb1f43471a8436617e3e48ae002021-11-05T10:13:34ZImaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study2234-943X10.3389/fonc.2021.723455https://doaj.org/article/9de406bb1f43471a8436617e3e48ae002021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.723455/fullhttps://doaj.org/toc/2234-943XObjectivesThere are still challenging problems in diagnosis of hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) before operation. This study aimed to analyze the imaging features of HCC with B1–B3 BDTT.Materials and MethodsThe clinicopathological data and imaging findings of 30 HCC patients with B1–B3 BDTT from three high-volume institutions were retrospectively reviewed. A total of 631 patients without BDTT who were randomly collected from each of the enrolled centers were recorded as the control group to analyze the differences in clinicopathological characteristics and imaging features between the two groups. A total of 453 HCC patients who underwent surgical treatment in the three institutions from January 2020 to December 2020 were collected for a blinded reading test as the validation group.ResultsHCC patients with B1–B3 BDTT had more advanced tumor stages and adverse clinicopathological features. HCC lesions were detected in all patients, and intrahepatic bile duct dilation was observed in 28 (93.3%) patients with B1–B3 BDTT and 9 (1.43%) patients in HCC without BDTT. The intrahepatic bile duct dilation showed no enhancement at hepatic arterial phase (HAP) and no progressively delayed enhancement at portal venous phase (PVP), but it was more obvious at PVP on CT. In the reports of the 30 HCC patients with B1–B3 BDTT generated for the image when the scan was done, BDTT was observed in all 13 B3 patients and 3 of 12 B2 patients, but none of the 5 B1 patients. Fourteen patients were misdiagnosed before surgery. However, when using intrahepatic bile duct dilation in HCC patients as a potential biomarker for BDTT diagnosis, the sensitivity and specificity for BDTT diagnosis were 93.33% and 98.57%, respectively. The blinded reading test showed that intrahepatic bile duct dilation in CT and MRI scans could be for separating HCC patients with B1–B3 BDTT from HCC patients without BDTT.ConclusionsThe HCC lesions and intrahepatic bile duct dilation on CT or MRI scans are imaging features of HCC with BDTT, which might facilitate the early diagnosis of B1–B3 BDTT.Jun-Yi WuJun-Yi WuLi-Ming HuangYan-Nan BaiYan-Nan BaiJia-Yi WuJia-Yi WuYong-Gang WeiZhi-Bo ZhangMao-Lin YanMao-Lin YanFrontiers Media S.A.articlehepatocellular carcinomabile duct tumor thrombuscomputed tomographymagnetic resonance imagingintrahepatic bile duct dilationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma bile duct tumor thrombus computed tomography magnetic resonance imaging intrahepatic bile duct dilation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma bile duct tumor thrombus computed tomography magnetic resonance imaging intrahepatic bile duct dilation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jun-Yi Wu Jun-Yi Wu Li-Ming Huang Yan-Nan Bai Yan-Nan Bai Jia-Yi Wu Jia-Yi Wu Yong-Gang Wei Zhi-Bo Zhang Mao-Lin Yan Mao-Lin Yan Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study
description	ObjectivesThere are still challenging problems in diagnosis of hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) before operation. This study aimed to analyze the imaging features of HCC with B1–B3 BDTT.Materials and MethodsThe clinicopathological data and imaging findings of 30 HCC patients with B1–B3 BDTT from three high-volume institutions were retrospectively reviewed. A total of 631 patients without BDTT who were randomly collected from each of the enrolled centers were recorded as the control group to analyze the differences in clinicopathological characteristics and imaging features between the two groups. A total of 453 HCC patients who underwent surgical treatment in the three institutions from January 2020 to December 2020 were collected for a blinded reading test as the validation group.ResultsHCC patients with B1–B3 BDTT had more advanced tumor stages and adverse clinicopathological features. HCC lesions were detected in all patients, and intrahepatic bile duct dilation was observed in 28 (93.3%) patients with B1–B3 BDTT and 9 (1.43%) patients in HCC without BDTT. The intrahepatic bile duct dilation showed no enhancement at hepatic arterial phase (HAP) and no progressively delayed enhancement at portal venous phase (PVP), but it was more obvious at PVP on CT. In the reports of the 30 HCC patients with B1–B3 BDTT generated for the image when the scan was done, BDTT was observed in all 13 B3 patients and 3 of 12 B2 patients, but none of the 5 B1 patients. Fourteen patients were misdiagnosed before surgery. However, when using intrahepatic bile duct dilation in HCC patients as a potential biomarker for BDTT diagnosis, the sensitivity and specificity for BDTT diagnosis were 93.33% and 98.57%, respectively. The blinded reading test showed that intrahepatic bile duct dilation in CT and MRI scans could be for separating HCC patients with B1–B3 BDTT from HCC patients without BDTT.ConclusionsThe HCC lesions and intrahepatic bile duct dilation on CT or MRI scans are imaging features of HCC with BDTT, which might facilitate the early diagnosis of B1–B3 BDTT.
format	article
author	Jun-Yi Wu Jun-Yi Wu Li-Ming Huang Yan-Nan Bai Yan-Nan Bai Jia-Yi Wu Jia-Yi Wu Yong-Gang Wei Zhi-Bo Zhang Mao-Lin Yan Mao-Lin Yan
author_facet	Jun-Yi Wu Jun-Yi Wu Li-Ming Huang Yan-Nan Bai Yan-Nan Bai Jia-Yi Wu Jia-Yi Wu Yong-Gang Wei Zhi-Bo Zhang Mao-Lin Yan Mao-Lin Yan
author_sort	Jun-Yi Wu
title	Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study
title_short	Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study
title_full	Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study
title_fullStr	Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study
title_full_unstemmed	Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study
title_sort	imaging features of hepatocellular carcinoma with bile duct tumor thrombus: a multicenter study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9de406bb1f43471a8436617e3e48ae00
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Imaging Features of Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: A Multicenter Study

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