Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation

Abstract Neurodegenerative diseases are characterized by neuronal impairment and loss of function, and with the major shared histopathological hallmarks of misfolding and aggregation of specific proteins inside or outside cells. Some genetic and environmental factors contribute to the promotion of t...

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Autores principales:	Hui Wang, Feng Yang, Shidong Zhang, Ruihua Xin, Yan Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9de71c10bf814a739aecd5b723905ec3
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spelling	oai:doaj.org-article:9de71c10bf814a739aecd5b723905ec32021-12-02T16:27:55ZGenetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation10.1038/s41531-021-00213-72373-8057https://doaj.org/article/9de71c10bf814a739aecd5b723905ec32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00213-7https://doaj.org/toc/2373-8057Abstract Neurodegenerative diseases are characterized by neuronal impairment and loss of function, and with the major shared histopathological hallmarks of misfolding and aggregation of specific proteins inside or outside cells. Some genetic and environmental factors contribute to the promotion of the development and progression of neurodegenerative diseases. Currently, there are no effective treatments for neurodegenerative diseases. It has been revealed that bidirectional communication exists between the brain and the gut. The gut microbiota is a changeable and experience-dependent ecosystem and can be modified by genetic and environmental factors. The gut microbiota provides potential therapeutic targets that can be regulated as new interventions for neurodegenerative diseases. In this review, we discuss genetic and environmental risk factors for neurodegenerative diseases, summarize the communication among the components of the microbiota-gut-brain axis, and discuss the treatment strategy of fecal microbiota transplantation (FMT). FMT is a promising treatment for neurodegenerative diseases, and restoration of the gut microbiota to a premorbid state is a novel goal for prevention and treatment strategies.Hui WangFeng YangShidong ZhangRuihua XinYan SunNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Hui Wang Feng Yang Shidong Zhang Ruihua Xin Yan Sun Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
description	Abstract Neurodegenerative diseases are characterized by neuronal impairment and loss of function, and with the major shared histopathological hallmarks of misfolding and aggregation of specific proteins inside or outside cells. Some genetic and environmental factors contribute to the promotion of the development and progression of neurodegenerative diseases. Currently, there are no effective treatments for neurodegenerative diseases. It has been revealed that bidirectional communication exists between the brain and the gut. The gut microbiota is a changeable and experience-dependent ecosystem and can be modified by genetic and environmental factors. The gut microbiota provides potential therapeutic targets that can be regulated as new interventions for neurodegenerative diseases. In this review, we discuss genetic and environmental risk factors for neurodegenerative diseases, summarize the communication among the components of the microbiota-gut-brain axis, and discuss the treatment strategy of fecal microbiota transplantation (FMT). FMT is a promising treatment for neurodegenerative diseases, and restoration of the gut microbiota to a premorbid state is a novel goal for prevention and treatment strategies.
format	article
author	Hui Wang Feng Yang Shidong Zhang Ruihua Xin Yan Sun
author_facet	Hui Wang Feng Yang Shidong Zhang Ruihua Xin Yan Sun
author_sort	Hui Wang
title	Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
title_short	Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
title_full	Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
title_fullStr	Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
title_full_unstemmed	Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
title_sort	genetic and environmental factors in alzheimer’s and parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9de71c10bf814a739aecd5b723905ec3
work_keys_str_mv	AT huiwang geneticandenvironmentalfactorsinalzheimersandparkinsonsdiseasesandpromisingtherapeuticinterventionviafecalmicrobiotatransplantation AT fengyang geneticandenvironmentalfactorsinalzheimersandparkinsonsdiseasesandpromisingtherapeuticinterventionviafecalmicrobiotatransplantation AT shidongzhang geneticandenvironmentalfactorsinalzheimersandparkinsonsdiseasesandpromisingtherapeuticinterventionviafecalmicrobiotatransplantation AT ruihuaxin geneticandenvironmentalfactorsinalzheimersandparkinsonsdiseasesandpromisingtherapeuticinterventionviafecalmicrobiotatransplantation AT yansun geneticandenvironmentalfactorsinalzheimersandparkinsonsdiseasesandpromisingtherapeuticinterventionviafecalmicrobiotatransplantation
_version_	1718384007556628480

Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation

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