The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease

Androgens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, the male reproductive and sexual function. Male hypogonadism, characterized by reduced testosterone, is commonly seen in ageing males...

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Autores principales:	Kristian Leisegang, Shubhadeep Roychoudhury, Petr Slama, Renata Finelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antioxidants noncommunicable chronic disease nutrition phytonutrients testosterone testosterone replacement therapy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/9de7509ad33e4594b1080f8d6ae50f73
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spelling	oai:doaj.org-article:9de7509ad33e4594b1080f8d6ae50f732021-11-25T16:29:29ZThe Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease10.3390/antiox101118342076-3921https://doaj.org/article/9de7509ad33e4594b1080f8d6ae50f732021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1834https://doaj.org/toc/2076-3921Androgens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, the male reproductive and sexual function. Male hypogonadism, characterized by reduced testosterone, is commonly seen in ageing males, and has a complex relationship as a risk factor and a comorbidity in age-related noncommunicable chronic diseases (NCDs), such as obesity, metabolic syndrome, type 2 diabetes, and malignancy. Oxidative stress, as a significant contributor to the ageing process, is a common feature between ageing and NCDs, and the related comorbidities, including hypertension, dyslipidemia, hyperglycemia, hyperinsulinemia, and chronic inflammation. Oxidative stress may also be a mediator of hypogonadism in males. Consequently, the management of oxidative stress may represent a novel therapeutic approach in this context. Therefore, this narrative review aims to discuss the mechanisms of age-related oxidative stress in male hypogonadism associated with NCDs and discusses current and potential approaches for the clinical management of these patients, which may include conventional hormone replacement therapy, nutrition and lifestyle changes, adherence to the optimal body mass index, and dietary antioxidant supplementation and/or phytomedicines.Kristian LeisegangShubhadeep RoychoudhuryPetr SlamaRenata FinelliMDPI AGarticleantioxidantsnoncommunicable chronic diseasenutritionphytonutrientstestosteronetestosterone replacement therapyTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1834, p 1834 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidants noncommunicable chronic disease nutrition phytonutrients testosterone testosterone replacement therapy Therapeutics. Pharmacology RM1-950
spellingShingle	antioxidants noncommunicable chronic disease nutrition phytonutrients testosterone testosterone replacement therapy Therapeutics. Pharmacology RM1-950 Kristian Leisegang Shubhadeep Roychoudhury Petr Slama Renata Finelli The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
description	Androgens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, the male reproductive and sexual function. Male hypogonadism, characterized by reduced testosterone, is commonly seen in ageing males, and has a complex relationship as a risk factor and a comorbidity in age-related noncommunicable chronic diseases (NCDs), such as obesity, metabolic syndrome, type 2 diabetes, and malignancy. Oxidative stress, as a significant contributor to the ageing process, is a common feature between ageing and NCDs, and the related comorbidities, including hypertension, dyslipidemia, hyperglycemia, hyperinsulinemia, and chronic inflammation. Oxidative stress may also be a mediator of hypogonadism in males. Consequently, the management of oxidative stress may represent a novel therapeutic approach in this context. Therefore, this narrative review aims to discuss the mechanisms of age-related oxidative stress in male hypogonadism associated with NCDs and discusses current and potential approaches for the clinical management of these patients, which may include conventional hormone replacement therapy, nutrition and lifestyle changes, adherence to the optimal body mass index, and dietary antioxidant supplementation and/or phytomedicines.
format	article
author	Kristian Leisegang Shubhadeep Roychoudhury Petr Slama Renata Finelli
author_facet	Kristian Leisegang Shubhadeep Roychoudhury Petr Slama Renata Finelli
author_sort	Kristian Leisegang
title	The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
title_short	The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
title_full	The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
title_fullStr	The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
title_full_unstemmed	The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease
title_sort	mechanisms and management of age-related oxidative stress in male hypogonadism associated with non-communicable chronic disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9de7509ad33e4594b1080f8d6ae50f73
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The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-communicable Chronic Disease

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