Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease

Abstract Background Moyamoya disease (MMD) is an uncommon cerebrovascular disease which leads to progressive stenosis and occlusion of the bilateral internal carotid artery and main intracerebral arteries. Concerns are always on how the hemisphere with infarction affects cognitive function, while li...

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Autores principales:	Ziqi Liu, Shihao He, Yanchang Wei, Ran Duan, Cai Zhang, Tian Li, Ning Ma, Xin Lou, Rong Wang, Xiaoyuan Liu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Moyamoya disease Stroke SBM Cortical complexity Fractal dimension Cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/9de791e1f005447592d76e440f4c6d95
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spelling	oai:doaj.org-article:9de791e1f005447592d76e440f4c6d952021-11-14T12:33:40ZChanges of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease10.1186/s12868-021-00672-x1471-2202https://doaj.org/article/9de791e1f005447592d76e440f4c6d952021-11-01T00:00:00Zhttps://doi.org/10.1186/s12868-021-00672-xhttps://doaj.org/toc/1471-2202Abstract Background Moyamoya disease (MMD) is an uncommon cerebrovascular disease which leads to progressive stenosis and occlusion of the bilateral internal carotid artery and main intracerebral arteries. Concerns are always on how the hemisphere with infarction affects cognitive function, while little attention is paid to the role that the non-infarcted hemisphere plays. Therefore, we aimed to detect cortical indexes, especially cortical complexity in the left or right hemisphere separately in patients with MMD after stroke. Methods 28 patients with MMD (14 males, 14 females) and 14 healthy controls were included in this study. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scan. The preprocessing of three-dimensional T1 weighted images were performed by standard surface-based morphometry. Surface-based morphometry statistical analysis was carried out with a threshold of False Discovery Rate (FDR) P < 0.05 and fractal dimension (FD) was used to provide a quantitative description of cerebral cortical complexity. Results Widespread cognitive dysfunctions were found in MMD patient with stroke. Extensive FD reduction in the left hemisphere with right-sided infarction, mainly in the superior temporal, inferior frontal, and insula, while the post central gyrus, superior parietal, and inferior parietal gyrus also showed a wide range of significant differences (FDR corrected P < 0.05). Meanwhile, FD changes in the right hemisphere with left-sided infarction are restricted to the precuneus and cingulate isthmus (FDR corrected P < 0.05). Conclusions Extensive cognitive impairment was reconfirmed in Moyamoya disease with stroke, while wild and asymmetrical decrease of cortical complexity is observed on both sides. These differences could be relative to unbalanced cognitive dysfunction, and may be the result of a long-term chronic ischemia and compensatory of the contralateral hemisphere to the infarction.Ziqi LiuShihao HeYanchang WeiRan DuanCai ZhangTian LiNing MaXin LouRong WangXiaoyuan LiuBMCarticleMoyamoya diseaseStrokeSBMCortical complexityFractal dimensionCognitive dysfunctionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurophysiology and neuropsychologyQP351-495ENBMC Neuroscience, Vol 22, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Moyamoya disease Stroke SBM Cortical complexity Fractal dimension Cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Moyamoya disease Stroke SBM Cortical complexity Fractal dimension Cognitive dysfunction Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495 Ziqi Liu Shihao He Yanchang Wei Ran Duan Cai Zhang Tian Li Ning Ma Xin Lou Rong Wang Xiaoyuan Liu Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease
description	Abstract Background Moyamoya disease (MMD) is an uncommon cerebrovascular disease which leads to progressive stenosis and occlusion of the bilateral internal carotid artery and main intracerebral arteries. Concerns are always on how the hemisphere with infarction affects cognitive function, while little attention is paid to the role that the non-infarcted hemisphere plays. Therefore, we aimed to detect cortical indexes, especially cortical complexity in the left or right hemisphere separately in patients with MMD after stroke. Methods 28 patients with MMD (14 males, 14 females) and 14 healthy controls were included in this study. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scan. The preprocessing of three-dimensional T1 weighted images were performed by standard surface-based morphometry. Surface-based morphometry statistical analysis was carried out with a threshold of False Discovery Rate (FDR) P < 0.05 and fractal dimension (FD) was used to provide a quantitative description of cerebral cortical complexity. Results Widespread cognitive dysfunctions were found in MMD patient with stroke. Extensive FD reduction in the left hemisphere with right-sided infarction, mainly in the superior temporal, inferior frontal, and insula, while the post central gyrus, superior parietal, and inferior parietal gyrus also showed a wide range of significant differences (FDR corrected P < 0.05). Meanwhile, FD changes in the right hemisphere with left-sided infarction are restricted to the precuneus and cingulate isthmus (FDR corrected P < 0.05). Conclusions Extensive cognitive impairment was reconfirmed in Moyamoya disease with stroke, while wild and asymmetrical decrease of cortical complexity is observed on both sides. These differences could be relative to unbalanced cognitive dysfunction, and may be the result of a long-term chronic ischemia and compensatory of the contralateral hemisphere to the infarction.
format	article
author	Ziqi Liu Shihao He Yanchang Wei Ran Duan Cai Zhang Tian Li Ning Ma Xin Lou Rong Wang Xiaoyuan Liu
author_facet	Ziqi Liu Shihao He Yanchang Wei Ran Duan Cai Zhang Tian Li Ning Ma Xin Lou Rong Wang Xiaoyuan Liu
author_sort	Ziqi Liu
title	Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease
title_short	Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease
title_full	Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease
title_fullStr	Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease
title_full_unstemmed	Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease
title_sort	changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9de791e1f005447592d76e440f4c6d95
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Changes of cerebral cortical structure and cognitive dysfunction in “healthy hemisphere” after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease

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