Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

Aging: Living longer by improving DNA repair Increasing levels of DNA repair factor Prp19 in fruit flies extends their life span and protects against stress. Prp19 is a protein that is present in a wide range of organisms and enables human endothelial cells to live longer in vitro. In this article,...

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Autores principales:	Kathrin Garschall, Hanna Dellago, Martina Gáliková, Markus Schosserer, Thomas Flatt, Johannes Grillari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/9de8dbacc3d34e688c868988a80c371f
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spelling	oai:doaj.org-article:9de8dbacc3d34e688c868988a80c371f2021-12-02T16:05:43ZUbiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span10.1038/s41514-017-0005-z2056-3973https://doaj.org/article/9de8dbacc3d34e688c868988a80c371f2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0005-zhttps://doaj.org/toc/2056-3973Aging: Living longer by improving DNA repair Increasing levels of DNA repair factor Prp19 in fruit flies extends their life span and protects against stress. Prp19 is a protein that is present in a wide range of organisms and enables human endothelial cells to live longer in vitro. In this article, an international team of scientists from Austria, Germany and Switzerland found that higher Prp19 levels also prolong the life span of a whole organism in fruit flies, reduce DNA damage and increase survival when exposed to DNA damaging compounds. In contrast to female flies, males were unaffected. Their findings support the long-held view that repair of DNA damage, one of the hallmarks of aging, is key to longevity. They also provide an intriguing but poorly understood connection between cellular aging and the survival of whole organisms.Kathrin GarschallHanna DellagoMartina GálikováMarkus SchossererThomas FlattJohannes GrillariNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Kathrin Garschall Hanna Dellago Martina Gáliková Markus Schosserer Thomas Flatt Johannes Grillari Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
description	Aging: Living longer by improving DNA repair Increasing levels of DNA repair factor Prp19 in fruit flies extends their life span and protects against stress. Prp19 is a protein that is present in a wide range of organisms and enables human endothelial cells to live longer in vitro. In this article, an international team of scientists from Austria, Germany and Switzerland found that higher Prp19 levels also prolong the life span of a whole organism in fruit flies, reduce DNA damage and increase survival when exposed to DNA damaging compounds. In contrast to female flies, males were unaffected. Their findings support the long-held view that repair of DNA damage, one of the hallmarks of aging, is key to longevity. They also provide an intriguing but poorly understood connection between cellular aging and the survival of whole organisms.
format	article
author	Kathrin Garschall Hanna Dellago Martina Gáliková Markus Schosserer Thomas Flatt Johannes Grillari
author_facet	Kathrin Garschall Hanna Dellago Martina Gáliková Markus Schosserer Thomas Flatt Johannes Grillari
author_sort	Kathrin Garschall
title	Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
title_short	Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
title_full	Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
title_fullStr	Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
title_full_unstemmed	Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
title_sort	ubiquitous overexpression of the dna repair factor dprp19 reduces dna damage and extends drosophila life span
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9de8dbacc3d34e688c868988a80c371f
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Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

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