Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish

The gene regulatory network controlling the bifurcation of common progenitors into the neural retina and retinal-pigmented epithelium programs remains poorly understood. Here the authors study transcriptome dynamics and chromatin accessibility during this process in zebrafish, revealing network redu...

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Autores principales:	Lorena Buono, Jorge Corbacho, Silvia Naranjo, María Almuedo-Castillo, Tania Moreno-Marmol, Berta de la Cerda, Estefanía Sanbria-Reinoso, Rocío Polvillo, Francisco-Javier Díaz-Corrales, Ozren Bogdanovic, Paola Bovolenta, Juan-Ramón Martínez-Morales
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9deb9ca050074c8e90fd83b3d7611510
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spelling	oai:doaj.org-article:9deb9ca050074c8e90fd83b3d76115102021-12-02T18:02:41ZAnalysis of gene network bifurcation during optic cup morphogenesis in zebrafish10.1038/s41467-021-24169-72041-1723https://doaj.org/article/9deb9ca050074c8e90fd83b3d76115102021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24169-7https://doaj.org/toc/2041-1723The gene regulatory network controlling the bifurcation of common progenitors into the neural retina and retinal-pigmented epithelium programs remains poorly understood. Here the authors study transcriptome dynamics and chromatin accessibility during this process in zebrafish, revealing network redundancy, as well as context-dependent and sequential transcription factor activity.Lorena BuonoJorge CorbachoSilvia NaranjoMaría Almuedo-CastilloTania Moreno-MarmolBerta de la CerdaEstefanía Sanbria-ReinosoRocío PolvilloFrancisco-Javier Díaz-CorralesOzren BogdanovicPaola BovolentaJuan-Ramón Martínez-MoralesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lorena Buono Jorge Corbacho Silvia Naranjo María Almuedo-Castillo Tania Moreno-Marmol Berta de la Cerda Estefanía Sanbria-Reinoso Rocío Polvillo Francisco-Javier Díaz-Corrales Ozren Bogdanovic Paola Bovolenta Juan-Ramón Martínez-Morales Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish
description	The gene regulatory network controlling the bifurcation of common progenitors into the neural retina and retinal-pigmented epithelium programs remains poorly understood. Here the authors study transcriptome dynamics and chromatin accessibility during this process in zebrafish, revealing network redundancy, as well as context-dependent and sequential transcription factor activity.
format	article
author	Lorena Buono Jorge Corbacho Silvia Naranjo María Almuedo-Castillo Tania Moreno-Marmol Berta de la Cerda Estefanía Sanbria-Reinoso Rocío Polvillo Francisco-Javier Díaz-Corrales Ozren Bogdanovic Paola Bovolenta Juan-Ramón Martínez-Morales
author_facet	Lorena Buono Jorge Corbacho Silvia Naranjo María Almuedo-Castillo Tania Moreno-Marmol Berta de la Cerda Estefanía Sanbria-Reinoso Rocío Polvillo Francisco-Javier Díaz-Corrales Ozren Bogdanovic Paola Bovolenta Juan-Ramón Martínez-Morales
author_sort	Lorena Buono
title	Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish
title_short	Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish
title_full	Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish
title_fullStr	Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish
title_full_unstemmed	Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish
title_sort	analysis of gene network bifurcation during optic cup morphogenesis in zebrafish
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9deb9ca050074c8e90fd83b3d7611510
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_version_	1718378884165009408

Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish

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