Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy

Chemotherapy is used widely for cancer treatment; however, the evolution of multidrug resistance (MDR) in many patients limits the therapeutic benefits of chemotherapy. It is important to overcome MDR for enhanced chemotherapy. ATP-dependent efflux of drugs out of cells is the main mechanism of MDR....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Minsu Kim, Seok Chan Park, Dong Yun Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glycyrrhizin multidrug resistance nitric oxide chemotherapy tumor microenvironment ATP-biding cassette Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9dec5a13662a4a3d94a9cdd862017644
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9dec5a13662a4a3d94a9cdd862017644
record_format	dspace
spelling	oai:doaj.org-article:9dec5a13662a4a3d94a9cdd8620176442021-11-25T17:03:42ZGlycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy10.3390/cancers132257622072-6694https://doaj.org/article/9dec5a13662a4a3d94a9cdd8620176442021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5762https://doaj.org/toc/2072-6694Chemotherapy is used widely for cancer treatment; however, the evolution of multidrug resistance (MDR) in many patients limits the therapeutic benefits of chemotherapy. It is important to overcome MDR for enhanced chemotherapy. ATP-dependent efflux of drugs out of cells is the main mechanism of MDR. Recent studies have suggested that nitric oxide (NO) can be used to overcome MDR by inhibiting the ATPase function of ATP-dependent pumps. Several attempts have been made to deliver NO to the tumor microenvironment (TME), however there are limitations in delivery. Glycyrrhizin (GL), an active compound of licorice, has been reported to both reduce the MDR effect by inhibiting ATP-dependent pumps and function as a regulator of NO production in the TME. In this review, we describe the potential role of GL as an NO regulator and MDR inhibitor that efficiently reduces the MDR effect in cancer chemotherapy.Minsu KimSeok Chan ParkDong Yun LeeMDPI AGarticleglycyrrhizinmultidrug resistancenitric oxidechemotherapytumor microenvironmentATP-biding cassetteNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5762, p 5762 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycyrrhizin multidrug resistance nitric oxide chemotherapy tumor microenvironment ATP-biding cassette Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	glycyrrhizin multidrug resistance nitric oxide chemotherapy tumor microenvironment ATP-biding cassette Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Minsu Kim Seok Chan Park Dong Yun Lee Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy
description	Chemotherapy is used widely for cancer treatment; however, the evolution of multidrug resistance (MDR) in many patients limits the therapeutic benefits of chemotherapy. It is important to overcome MDR for enhanced chemotherapy. ATP-dependent efflux of drugs out of cells is the main mechanism of MDR. Recent studies have suggested that nitric oxide (NO) can be used to overcome MDR by inhibiting the ATPase function of ATP-dependent pumps. Several attempts have been made to deliver NO to the tumor microenvironment (TME), however there are limitations in delivery. Glycyrrhizin (GL), an active compound of licorice, has been reported to both reduce the MDR effect by inhibiting ATP-dependent pumps and function as a regulator of NO production in the TME. In this review, we describe the potential role of GL as an NO regulator and MDR inhibitor that efficiently reduces the MDR effect in cancer chemotherapy.
format	article
author	Minsu Kim Seok Chan Park Dong Yun Lee
author_facet	Minsu Kim Seok Chan Park Dong Yun Lee
author_sort	Minsu Kim
title	Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy
title_short	Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy
title_full	Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy
title_fullStr	Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy
title_full_unstemmed	Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy
title_sort	glycyrrhizin as a nitric oxide regulator in cancer chemotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9dec5a13662a4a3d94a9cdd862017644
work_keys_str_mv	AT minsukim glycyrrhizinasanitricoxideregulatorincancerchemotherapy AT seokchanpark glycyrrhizinasanitricoxideregulatorincancerchemotherapy AT dongyunlee glycyrrhizinasanitricoxideregulatorincancerchemotherapy
_version_	1718412792177885184

Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy

Ejemplares similares