MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

Kinase inhibitors are widely used to treat cancer, however patients frequently develop resistance. Here, the authors investigate adaption mechanisms during drug persistence and show that stimulation of the innate immunity sensor RIG-I enhances cancer cell death when combined with kinase inhibition.

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Autores principales:	Johannes Brägelmann, Carina Lorenz, Sven Borchmann, Kazuya Nishii, Julia Wegner, Lydia Meder, Jenny Ostendorp, David F. Ast, Alena Heimsoeth, Takamasa Nakasuka, Atsuko Hirabae, Sachi Okawa, Marcel A. Dammert, Dennis Plenker, Sebastian Klein, Philipp Lohneis, Jianing Gu, Laura K. Godfrey, Jan Forster, Marija Trajkovic-Arsic, Thomas Zillinger, Mareike Haarmann, Alexander Quaas, Stefanie Lennartz, Marcel Schmiel, Joshua D’Rozario, Emily S. Thomas, Henry Li, Clemens A. Schmitt, Julie George, Roman K. Thomas, Silvia von Karstedt, Gunther Hartmann, Reinhard Büttner, Roland T. Ullrich, Jens T. Siveke, Kadoaki Ohashi, Martin Schlee, Martin L. Sos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9def69d01bbd4809814653393e15ac1f
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spelling	oai:doaj.org-article:9def69d01bbd4809814653393e15ac1f2021-12-02T15:16:10ZMAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I10.1038/s41467-021-25728-82041-1723https://doaj.org/article/9def69d01bbd4809814653393e15ac1f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25728-8https://doaj.org/toc/2041-1723Kinase inhibitors are widely used to treat cancer, however patients frequently develop resistance. Here, the authors investigate adaption mechanisms during drug persistence and show that stimulation of the innate immunity sensor RIG-I enhances cancer cell death when combined with kinase inhibition.Johannes BrägelmannCarina LorenzSven BorchmannKazuya NishiiJulia WegnerLydia MederJenny OstendorpDavid F. AstAlena HeimsoethTakamasa NakasukaAtsuko HirabaeSachi OkawaMarcel A. DammertDennis PlenkerSebastian KleinPhilipp LohneisJianing GuLaura K. GodfreyJan ForsterMarija Trajkovic-ArsicThomas ZillingerMareike HaarmannAlexander QuaasStefanie LennartzMarcel SchmielJoshua D’RozarioEmily S. ThomasHenry LiClemens A. SchmittJulie GeorgeRoman K. ThomasSilvia von KarstedtGunther HartmannReinhard BüttnerRoland T. UllrichJens T. SivekeKadoaki OhashiMartin SchleeMartin L. SosNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Johannes Brägelmann Carina Lorenz Sven Borchmann Kazuya Nishii Julia Wegner Lydia Meder Jenny Ostendorp David F. Ast Alena Heimsoeth Takamasa Nakasuka Atsuko Hirabae Sachi Okawa Marcel A. Dammert Dennis Plenker Sebastian Klein Philipp Lohneis Jianing Gu Laura K. Godfrey Jan Forster Marija Trajkovic-Arsic Thomas Zillinger Mareike Haarmann Alexander Quaas Stefanie Lennartz Marcel Schmiel Joshua D’Rozario Emily S. Thomas Henry Li Clemens A. Schmitt Julie George Roman K. Thomas Silvia von Karstedt Gunther Hartmann Reinhard Büttner Roland T. Ullrich Jens T. Siveke Kadoaki Ohashi Martin Schlee Martin L. Sos MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I
description	Kinase inhibitors are widely used to treat cancer, however patients frequently develop resistance. Here, the authors investigate adaption mechanisms during drug persistence and show that stimulation of the innate immunity sensor RIG-I enhances cancer cell death when combined with kinase inhibition.
format	article
author	Johannes Brägelmann Carina Lorenz Sven Borchmann Kazuya Nishii Julia Wegner Lydia Meder Jenny Ostendorp David F. Ast Alena Heimsoeth Takamasa Nakasuka Atsuko Hirabae Sachi Okawa Marcel A. Dammert Dennis Plenker Sebastian Klein Philipp Lohneis Jianing Gu Laura K. Godfrey Jan Forster Marija Trajkovic-Arsic Thomas Zillinger Mareike Haarmann Alexander Quaas Stefanie Lennartz Marcel Schmiel Joshua D’Rozario Emily S. Thomas Henry Li Clemens A. Schmitt Julie George Roman K. Thomas Silvia von Karstedt Gunther Hartmann Reinhard Büttner Roland T. Ullrich Jens T. Siveke Kadoaki Ohashi Martin Schlee Martin L. Sos
author_facet	Johannes Brägelmann Carina Lorenz Sven Borchmann Kazuya Nishii Julia Wegner Lydia Meder Jenny Ostendorp David F. Ast Alena Heimsoeth Takamasa Nakasuka Atsuko Hirabae Sachi Okawa Marcel A. Dammert Dennis Plenker Sebastian Klein Philipp Lohneis Jianing Gu Laura K. Godfrey Jan Forster Marija Trajkovic-Arsic Thomas Zillinger Mareike Haarmann Alexander Quaas Stefanie Lennartz Marcel Schmiel Joshua D’Rozario Emily S. Thomas Henry Li Clemens A. Schmitt Julie George Roman K. Thomas Silvia von Karstedt Gunther Hartmann Reinhard Büttner Roland T. Ullrich Jens T. Siveke Kadoaki Ohashi Martin Schlee Martin L. Sos
author_sort	Johannes Brägelmann
title	MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I
title_short	MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I
title_full	MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I
title_fullStr	MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I
title_full_unstemmed	MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I
title_sort	mapk-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor rig-i
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9def69d01bbd4809814653393e15ac1f
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MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

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