The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea
Cynthia Matossian,1 Xue Song,2 Ishveen Chopra,2 Amy Sainski-Nguyen,2 Abayomi Ogundele3 1Matossian Eye Associates, Doylestown, PA, USA; 2Outcomes Research, IBM Watson Health, Cambridge, MA, USA; 3Medical Affairs, Sun Pharmaceutical Industries, Inc., Princeton, NJ, USACorrespondence: Abayomi Ogundele...
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Dove Medical Press
2020
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oai:doaj.org-article:9defc5eece554a06922ec9c2681d55cc2021-12-02T11:21:00ZThe Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea1177-5483https://doaj.org/article/9defc5eece554a06922ec9c2681d55cc2020-10-01T00:00:00Zhttps://www.dovepress.com/the-prevalence-and-incidence-of-dry-eye-disease-among-patients-using-c-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Cynthia Matossian,1 Xue Song,2 Ishveen Chopra,2 Amy Sainski-Nguyen,2 Abayomi Ogundele3 1Matossian Eye Associates, Doylestown, PA, USA; 2Outcomes Research, IBM Watson Health, Cambridge, MA, USA; 3Medical Affairs, Sun Pharmaceutical Industries, Inc., Princeton, NJ, USACorrespondence: Abayomi Ogundele Email Abayomi.Ogundele@sunpharma.comIntroduction: Dry eye disease (DED) prevalence is estimated at 9.3% of the US adult population, although diagnosed rate is much lower. This study examined real-world incidence rates (IR) and prevalence rates (PR) of DED in adults using continuous positive airway pressure (CPAP) or nasal mask therapy (NMT) devices to treat sleep apnea.Methods: Using IBM MarketScan Commercial and Medicare Supplemental claims databases, this study identified adults with ≥ 1 claim of CPAP or other NMT device between January 1, 2014 and June 30, 2018, ≥ 1 diagnosis of sleep apnea during a 12-month pre-index period, and continuous benefit enrollment ≥ 12 pre- and post-index date. The date of the first CPAP or NMT device claim was considered the index date. Descriptive analyses included PR, IR, and IR per 100-person years (100PY) for the overall population and subgroups including age, sex, and baseline comorbidities.Results: The 1-, 2-, and 3-year PR of DED was 6.2%, 10.0%, and 13.0%, while the IR of DED was 4.0%, 7.3%, and 10.3%, respectively. Females had a higher IR of DED compared to males: 5.8%, 10.8%, and 15.1% vs 3.0%, 5.4%, and 7.9%, respectively. DED increased with age with a 1-, 2-, and 3-year PR for patients aged 18– 24 years of 2.2%, 3.4%, and 5.0% vs 17.6%, 25.8%, and 32.1% in patients aged ≥ 75, respectively. Overall, IR per 100PY of DED was 3.68, higher for females than males (5.51 vs 2.73). PR and IR of DED were high among patients with comorbid inflammatory or metabolic conditions.Conclusion: The PR and IR of DED in CPAP or NMT users were higher than the reported prevalence of DED in the general population. CPAP/NMT users who were female, older, or had comorbid inflammatory or metabolic conditions may experience a higher incidence and prevalence of DED.Keywords: dry eye disease, obstructive sleep apnea, prevalence rate, incidence rate, CPAP, nasal mask therapy deviceMatossian CSong XChopra ISainski-Nguyen AOgundele ADove Medical Pressarticledry eye diseaseobstructive sleep apneaprevalence rateincidence ratecpapnasal mask therapy deviceOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3371-3379 (2020) |
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dry eye disease obstructive sleep apnea prevalence rate incidence rate cpap nasal mask therapy device Ophthalmology RE1-994 |
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dry eye disease obstructive sleep apnea prevalence rate incidence rate cpap nasal mask therapy device Ophthalmology RE1-994 Matossian C Song X Chopra I Sainski-Nguyen A Ogundele A The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea |
| description |
Cynthia Matossian,1 Xue Song,2 Ishveen Chopra,2 Amy Sainski-Nguyen,2 Abayomi Ogundele3 1Matossian Eye Associates, Doylestown, PA, USA; 2Outcomes Research, IBM Watson Health, Cambridge, MA, USA; 3Medical Affairs, Sun Pharmaceutical Industries, Inc., Princeton, NJ, USACorrespondence: Abayomi Ogundele Email Abayomi.Ogundele@sunpharma.comIntroduction: Dry eye disease (DED) prevalence is estimated at 9.3% of the US adult population, although diagnosed rate is much lower. This study examined real-world incidence rates (IR) and prevalence rates (PR) of DED in adults using continuous positive airway pressure (CPAP) or nasal mask therapy (NMT) devices to treat sleep apnea.Methods: Using IBM MarketScan Commercial and Medicare Supplemental claims databases, this study identified adults with ≥ 1 claim of CPAP or other NMT device between January 1, 2014 and June 30, 2018, ≥ 1 diagnosis of sleep apnea during a 12-month pre-index period, and continuous benefit enrollment ≥ 12 pre- and post-index date. The date of the first CPAP or NMT device claim was considered the index date. Descriptive analyses included PR, IR, and IR per 100-person years (100PY) for the overall population and subgroups including age, sex, and baseline comorbidities.Results: The 1-, 2-, and 3-year PR of DED was 6.2%, 10.0%, and 13.0%, while the IR of DED was 4.0%, 7.3%, and 10.3%, respectively. Females had a higher IR of DED compared to males: 5.8%, 10.8%, and 15.1% vs 3.0%, 5.4%, and 7.9%, respectively. DED increased with age with a 1-, 2-, and 3-year PR for patients aged 18– 24 years of 2.2%, 3.4%, and 5.0% vs 17.6%, 25.8%, and 32.1% in patients aged ≥ 75, respectively. Overall, IR per 100PY of DED was 3.68, higher for females than males (5.51 vs 2.73). PR and IR of DED were high among patients with comorbid inflammatory or metabolic conditions.Conclusion: The PR and IR of DED in CPAP or NMT users were higher than the reported prevalence of DED in the general population. CPAP/NMT users who were female, older, or had comorbid inflammatory or metabolic conditions may experience a higher incidence and prevalence of DED.Keywords: dry eye disease, obstructive sleep apnea, prevalence rate, incidence rate, CPAP, nasal mask therapy device |
| format |
article |
| author |
Matossian C Song X Chopra I Sainski-Nguyen A Ogundele A |
| author_facet |
Matossian C Song X Chopra I Sainski-Nguyen A Ogundele A |
| author_sort |
Matossian C |
| title |
The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea |
| title_short |
The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea |
| title_full |
The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea |
| title_fullStr |
The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea |
| title_full_unstemmed |
The Prevalence and Incidence of Dry Eye Disease Among Patients Using Continuous Positive Airway Pressure or Other Nasal Mask Therapy Devices to Treat Sleep Apnea |
| title_sort |
prevalence and incidence of dry eye disease among patients using continuous positive airway pressure or other nasal mask therapy devices to treat sleep apnea |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/9defc5eece554a06922ec9c2681d55cc |
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