Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review

Eric W Schneider, Mark W JohnsonDepartment of Ophthalmology and Visual Sciences, University of Michigan, WK Kellogg Eye Center, Ann Arbor, MI, USAAbstract: With the dissemination of optical coherence tomography over the past two decades, the role of persistent vitreomacular adhesion (VMA) in the dev...

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Autores principales:	Schneider EW, Johnson MW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/9defe01141d5456c9cddc1a5e58e5cb3
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spelling	oai:doaj.org-article:9defe01141d5456c9cddc1a5e58e5cb32021-12-02T02:39:46ZEmerging nonsurgical methods for the treatment of vitreomacular adhesion: a review1177-54671177-5483https://doaj.org/article/9defe01141d5456c9cddc1a5e58e5cb32011-08-01T00:00:00Zhttp://www.dovepress.com/emerging-nonsurgical-methods-for-the-treatment-of-vitreomacular-adhesi-a8103https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Eric W Schneider, Mark W JohnsonDepartment of Ophthalmology and Visual Sciences, University of Michigan, WK Kellogg Eye Center, Ann Arbor, MI, USAAbstract: With the dissemination of optical coherence tomography over the past two decades, the role of persistent vitreomacular adhesion (VMA) in the development of numerous macular pathologies &ndash; including idiopathic macular hole, vitreomacular traction syndrome, cystoid and diabetic macular edema, neovascularization in diabetic retinopathy and retinal vein occlusion, exudative age-related macular degeneration, and myopic traction maculopathy &ndash; has been established. While invasive vitreoretinal procedures have long been utilized to address complications related to these disorders, such an approach is hampered by incomplete vitreoretinal separation and vitreous removal, surgical complications, and high costs. In light of such limitations, investigators have increasingly looked to nonsurgical means for the treatment of persistent pathologic VMA. Chief among these alternative measures is the intravitreal application of pharmacologic agents for the induction of vitreous liquefaction and/or vitreoretinal separation, an approach termed pharmacologic vitreolysis. This article aims to review the available evidence regarding the use of pharmacologic agents in the treatment of VMA-related pathology. In addition, a discussion of vitreous molecular organization and principles of physiologic posterior vitreous detachment is provided to allow for a consideration of vitreolytic agent mode of action and molecular targets.Keywords: macular edema, macular hole, microplasmin, pharmacologic vitreolysis, posterior vitreous detachment, vitreomacular traction syndromeSchneider EWJohnson MWDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1151-1165 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Schneider EW Johnson MW Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review
description	Eric W Schneider, Mark W JohnsonDepartment of Ophthalmology and Visual Sciences, University of Michigan, WK Kellogg Eye Center, Ann Arbor, MI, USAAbstract: With the dissemination of optical coherence tomography over the past two decades, the role of persistent vitreomacular adhesion (VMA) in the development of numerous macular pathologies &ndash; including idiopathic macular hole, vitreomacular traction syndrome, cystoid and diabetic macular edema, neovascularization in diabetic retinopathy and retinal vein occlusion, exudative age-related macular degeneration, and myopic traction maculopathy &ndash; has been established. While invasive vitreoretinal procedures have long been utilized to address complications related to these disorders, such an approach is hampered by incomplete vitreoretinal separation and vitreous removal, surgical complications, and high costs. In light of such limitations, investigators have increasingly looked to nonsurgical means for the treatment of persistent pathologic VMA. Chief among these alternative measures is the intravitreal application of pharmacologic agents for the induction of vitreous liquefaction and/or vitreoretinal separation, an approach termed pharmacologic vitreolysis. This article aims to review the available evidence regarding the use of pharmacologic agents in the treatment of VMA-related pathology. In addition, a discussion of vitreous molecular organization and principles of physiologic posterior vitreous detachment is provided to allow for a consideration of vitreolytic agent mode of action and molecular targets.Keywords: macular edema, macular hole, microplasmin, pharmacologic vitreolysis, posterior vitreous detachment, vitreomacular traction syndrome
format	article
author	Schneider EW Johnson MW
author_facet	Schneider EW Johnson MW
author_sort	Schneider EW
title	Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review
title_short	Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review
title_full	Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review
title_fullStr	Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review
title_full_unstemmed	Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review
title_sort	emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/9defe01141d5456c9cddc1a5e58e5cb3
work_keys_str_mv	AT schneiderew emergingnonsurgicalmethodsforthetreatmentofvitreomacularadhesionareview AT johnsonmw emergingnonsurgicalmethodsforthetreatmentofvitreomacularadhesionareview
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Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review

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