Examining the Association Between Serum Leptin and Sarcopenic Obesity

Zhe-Yu Yang,1,2 Wei-Liang Chen2– 4 1Department of General Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 2Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and S...

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Autores principales:	Yang ZY, Chen WL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	serum leptin levels sarcopenia sarcopenic obesity Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/9df2ad5b4f9948b6ba69bbde9f60f11b
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spelling	oai:doaj.org-article:9df2ad5b4f9948b6ba69bbde9f60f11b2021-12-02T16:27:21ZExamining the Association Between Serum Leptin and Sarcopenic Obesity1178-7031https://doaj.org/article/9df2ad5b4f9948b6ba69bbde9f60f11b2021-07-01T00:00:00Zhttps://www.dovepress.com/examining-the-association-between-serum-leptin-and-sarcopenic-obesity-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Zhe-Yu Yang,1,2 Wei-Liang Chen2– 4 1Department of General Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 2Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 3Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 4Department of Biochemistry, National Defense Medical Center, Taiwan, Republic of ChinaCorrespondence: Wei-Liang ChenDivision of Geriatric Medicine, Department of Family Medicine, Tri-Service General Hospital, National Defense Medical Center, Number 325, Section 2, Chang-gong Road, Nei-Hu District, 114, Taipei, TaiwanTel +886-2-87923311 ext. 16567Fax +886-2-87927057Email weiliang0508@gmail.comObjective: Sarcopenic obesity is an emerging geriatric syndrome among elderly individuals. Studies revealed a complicated pathogenesis between sarcopenia and obesity. Leptin, a proinflammatory adipokine, has been implicated in the mechanism of sarcopenic obesity. This study investigated the relationship between serum leptin level and sarcopenic obesity.Methods: The study included 4063 participants aged 60 years and older from the NHANES III database. Sarcopenia was defined as a skeletal muscle index (SMI) less than one standard deviation below the young adult value. Obesity was defined as a body mass index (BMIF) over 30 kg/m2. Multivariate regression analysis was performed to examine the association between serum leptin level and sarcopenic obesity.Results: In adjusted models, serum leptin level was positively correlated with BMI (β: 1.33, p value < 0.001) and negatively correlated with SMI (β: − 0.091, p value = 0.001). A significant association between serum leptin level and sarcopenic obesity was found in multivariate analysis (β: 4.011, p value=0.014).Conclusion: Our study demonstrated that serum leptin level was related to an increased risk of sarcopenic obesity. This epidemiologic finding suggests that leptin may play a role in sarcopenic obesity.Keywords: serum leptin levels, sarcopenia, sarcopenic obesityYang ZYChen WLDove Medical Pressarticleserum leptin levelssarcopeniasarcopenic obesityPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 3481-3487 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	serum leptin levels sarcopenia sarcopenic obesity Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	serum leptin levels sarcopenia sarcopenic obesity Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Yang ZY Chen WL Examining the Association Between Serum Leptin and Sarcopenic Obesity
description	Zhe-Yu Yang,1,2 Wei-Liang Chen2– 4 1Department of General Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 2Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 3Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China; 4Department of Biochemistry, National Defense Medical Center, Taiwan, Republic of ChinaCorrespondence: Wei-Liang ChenDivision of Geriatric Medicine, Department of Family Medicine, Tri-Service General Hospital, National Defense Medical Center, Number 325, Section 2, Chang-gong Road, Nei-Hu District, 114, Taipei, TaiwanTel +886-2-87923311 ext. 16567Fax +886-2-87927057Email weiliang0508@gmail.comObjective: Sarcopenic obesity is an emerging geriatric syndrome among elderly individuals. Studies revealed a complicated pathogenesis between sarcopenia and obesity. Leptin, a proinflammatory adipokine, has been implicated in the mechanism of sarcopenic obesity. This study investigated the relationship between serum leptin level and sarcopenic obesity.Methods: The study included 4063 participants aged 60 years and older from the NHANES III database. Sarcopenia was defined as a skeletal muscle index (SMI) less than one standard deviation below the young adult value. Obesity was defined as a body mass index (BMIF) over 30 kg/m2. Multivariate regression analysis was performed to examine the association between serum leptin level and sarcopenic obesity.Results: In adjusted models, serum leptin level was positively correlated with BMI (β: 1.33, p value < 0.001) and negatively correlated with SMI (β: − 0.091, p value = 0.001). A significant association between serum leptin level and sarcopenic obesity was found in multivariate analysis (β: 4.011, p value=0.014).Conclusion: Our study demonstrated that serum leptin level was related to an increased risk of sarcopenic obesity. This epidemiologic finding suggests that leptin may play a role in sarcopenic obesity.Keywords: serum leptin levels, sarcopenia, sarcopenic obesity
format	article
author	Yang ZY Chen WL
author_facet	Yang ZY Chen WL
author_sort	Yang ZY
title	Examining the Association Between Serum Leptin and Sarcopenic Obesity
title_short	Examining the Association Between Serum Leptin and Sarcopenic Obesity
title_full	Examining the Association Between Serum Leptin and Sarcopenic Obesity
title_fullStr	Examining the Association Between Serum Leptin and Sarcopenic Obesity
title_full_unstemmed	Examining the Association Between Serum Leptin and Sarcopenic Obesity
title_sort	examining the association between serum leptin and sarcopenic obesity
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9df2ad5b4f9948b6ba69bbde9f60f11b
work_keys_str_mv	AT yangzy examiningtheassociationbetweenserumleptinandsarcopenicobesity AT chenwl examiningtheassociationbetweenserumleptinandsarcopenicobesity
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Examining the Association Between Serum Leptin and Sarcopenic Obesity

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