Nontypeable <italic toggle="yes">Haemophilus influenzae</italic> Has Evolved Preferential Use of <italic toggle="yes">N-</italic>Acetylneuraminic Acid as a Host Adaptation

Nontypeable <italic toggle="yes">Haemophilus influenzae</italic> Has Evolved Preferential Use of <italic toggle="yes">N-</italic>Acetylneuraminic Acid as a Host Adaptation

ABSTRACT Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glycolipid lipooligosaccharide (LOS). Sialic acid expressed on...

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Bibliographic Details
Main Authors: Preston S. K. Ng, Christopher J. Day, John M. Atack, Lauren E. Hartley-Tassell, Linda E. Winter, Tal Marshanski, Vered Padler-Karavani, Ajit Varki, Stephen J. Barenkamp, Michael A. Apicella, Michael P. Jennings
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
Haemophilus influenzae
bacterial metabolism
glycobiology
microbial pathogenesis
sialic acid
Microbiology
QR1-502
Online Access:https://doaj.org/article/9df602e01e3944e69c87d40bbd3d2636
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