An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis

Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior, stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its binding to the oxytocin receptor, coded for by the OXTR gene. Many studies have examined the role of epigenetic regulatio...

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Autores principales:	Joshua S. Danoff, Jessica J. Connelly, James P. Morris, Allison M. Perkeybile
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Oxytocin receptor OXTR DNA methylation Allostasis Early life experience Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990
Acceso en línea:	https://doaj.org/article/9df81b2664eb4ab7bbdc0bee465196f2
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spelling	oai:doaj.org-article:9df81b2664eb4ab7bbdc0bee465196f22021-11-20T05:14:31ZAn epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis2666-497610.1016/j.cpnec.2021.100098https://doaj.org/article/9df81b2664eb4ab7bbdc0bee465196f22021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666497621000722https://doaj.org/toc/2666-4976Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior, stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its binding to the oxytocin receptor, coded for by the OXTR gene. Many studies have examined the role of epigenetic regulation of OXTR in neurological and behavioral outcomes in both humans and animal models. Here, we review these studies, critically analyze their findings in the context of oxytocin's role as an allostatic hormone, and provide suggestions for future research. We use OXTR as a model for how those in the field of psychoneuroendocrinology should perform epigenetic studies in order to maximize both biological relevance and potential for biomarker development.Joshua S. DanoffJessica J. ConnellyJames P. MorrisAllison M. PerkeybileElsevierarticleOxytocin receptorOXTRDNA methylationAllostasisEarly life experienceNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571PsychologyBF1-990ENComprehensive Psychoneuroendocrinology, Vol 8, Iss , Pp 100098- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oxytocin receptor OXTR DNA methylation Allostasis Early life experience Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990
spellingShingle	Oxytocin receptor OXTR DNA methylation Allostasis Early life experience Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Psychology BF1-990 Joshua S. Danoff Jessica J. Connelly James P. Morris Allison M. Perkeybile An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis
description	Oxytocin is a neuropeptide hormone which is involved in regulation of social behavior, stress response, muscle contraction, and metabolism. Oxytocin signaling is dependent on its binding to the oxytocin receptor, coded for by the OXTR gene. Many studies have examined the role of epigenetic regulation of OXTR in neurological and behavioral outcomes in both humans and animal models. Here, we review these studies, critically analyze their findings in the context of oxytocin's role as an allostatic hormone, and provide suggestions for future research. We use OXTR as a model for how those in the field of psychoneuroendocrinology should perform epigenetic studies in order to maximize both biological relevance and potential for biomarker development.
format	article
author	Joshua S. Danoff Jessica J. Connelly James P. Morris Allison M. Perkeybile
author_facet	Joshua S. Danoff Jessica J. Connelly James P. Morris Allison M. Perkeybile
author_sort	Joshua S. Danoff
title	An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis
title_short	An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis
title_full	An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis
title_fullStr	An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis
title_full_unstemmed	An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis
title_sort	epigenetic rheostat of experience: dna methylation of oxtr as a mechanism of early life allostasis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9df81b2664eb4ab7bbdc0bee465196f2
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An epigenetic rheostat of experience: DNA methylation of OXTR as a mechanism of early life allostasis

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