The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

Gene fusions involving MLL and different partner genes define unique subgroups of acute myelogenous leukemia, but the mechanisms underlying specific subgroups are not fully clear. Here the authors elucidate the mechanisms of MLL-AF6 induced transformation, providing a distinct pathway that involves...

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Autores principales: Akihiko Numata, Hui Si Kwok, Akira Kawasaki, Jia Li, Qi-Ling Zhou, Jon Kerry, Touati Benoukraf, Deepak Bararia, Feng Li, Erica Ballabio, Marta Tapia, Aniruddha J. Deshpande, Robert S. Welner, Ruud Delwel, Henry Yang, Thomas A. Milne, Reshma Taneja, Daniel G. Tenen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/9dfa107dbcde4625a8ba0c6b7e56e898
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spelling oai:doaj.org-article:9dfa107dbcde4625a8ba0c6b7e56e8982021-12-02T16:49:21ZThe basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia10.1038/s41467-018-03854-02041-1723https://doaj.org/article/9dfa107dbcde4625a8ba0c6b7e56e8982018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03854-0https://doaj.org/toc/2041-1723Gene fusions involving MLL and different partner genes define unique subgroups of acute myelogenous leukemia, but the mechanisms underlying specific subgroups are not fully clear. Here the authors elucidate the mechanisms of MLL-AF6 induced transformation, providing a distinct pathway that involves SHARP1 as a critical target.Akihiko NumataHui Si KwokAkira KawasakiJia LiQi-Ling ZhouJon KerryTouati BenoukrafDeepak BarariaFeng LiErica BallabioMarta TapiaAniruddha J. DeshpandeRobert S. WelnerRuud DelwelHenry YangThomas A. MilneReshma TanejaDaniel G. TenenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Akihiko Numata
Hui Si Kwok
Akira Kawasaki
Jia Li
Qi-Ling Zhou
Jon Kerry
Touati Benoukraf
Deepak Bararia
Feng Li
Erica Ballabio
Marta Tapia
Aniruddha J. Deshpande
Robert S. Welner
Ruud Delwel
Henry Yang
Thomas A. Milne
Reshma Taneja
Daniel G. Tenen
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
description Gene fusions involving MLL and different partner genes define unique subgroups of acute myelogenous leukemia, but the mechanisms underlying specific subgroups are not fully clear. Here the authors elucidate the mechanisms of MLL-AF6 induced transformation, providing a distinct pathway that involves SHARP1 as a critical target.
format article
author Akihiko Numata
Hui Si Kwok
Akira Kawasaki
Jia Li
Qi-Ling Zhou
Jon Kerry
Touati Benoukraf
Deepak Bararia
Feng Li
Erica Ballabio
Marta Tapia
Aniruddha J. Deshpande
Robert S. Welner
Ruud Delwel
Henry Yang
Thomas A. Milne
Reshma Taneja
Daniel G. Tenen
author_facet Akihiko Numata
Hui Si Kwok
Akira Kawasaki
Jia Li
Qi-Ling Zhou
Jon Kerry
Touati Benoukraf
Deepak Bararia
Feng Li
Erica Ballabio
Marta Tapia
Aniruddha J. Deshpande
Robert S. Welner
Ruud Delwel
Henry Yang
Thomas A. Milne
Reshma Taneja
Daniel G. Tenen
author_sort Akihiko Numata
title The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
title_short The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
title_full The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
title_fullStr The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
title_full_unstemmed The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
title_sort basic helix-loop-helix transcription factor sharp1 is an oncogenic driver in mll-af6 acute myelogenous leukemia
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/9dfa107dbcde4625a8ba0c6b7e56e898
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