Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition

Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition

Abstract The PfRh5-Basigin ligand–receptor interaction is an essential step in the merozoite invasion process and represents an attractive vaccine target. To reveal genotype–phenotype associations between naturally occurring allelic variants of PfRh5 and invasion inhibition, we performed ex vivo inv...

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Autores principales: Adam J. Moore, Khadidiatou Mangou, Fatoumata Diallo, Seynabou D. Sene, Mariama N. Pouye, Bacary D. Sadio, Ousmane Faye, Alassane Mbengue, Amy K. Bei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9dfa5e505d1c455888d29f291b816639
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