Human exome sequence data in support of somatic mosaicism in carotid atherosclerosis

Understanding the mechanisms underlying the connection between somatic mosaicism and cardiovascular disease is likely essential for the future of personalized medicine. This article is aimed at providing data on somatic mosaicism in human carotid atherosclerosis. An advanced carotid atherosclerotic...

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Autores principales:	Alexei A. Sleptcov, Alexei A. Zarubin, Polina M. Bogaychuk, Mikhail S. Kuznetsov, Boris N. Kozlov, Maria S. Nazarenko
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Atherosclerosis Carotid plaque Exome sequencing HiSeq Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/9dfae944c61d44c38816ba03018bb113
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spelling	oai:doaj.org-article:9dfae944c61d44c38816ba03018bb1132021-12-04T04:34:39ZHuman exome sequence data in support of somatic mosaicism in carotid atherosclerosis2352-340910.1016/j.dib.2021.107656https://doaj.org/article/9dfae944c61d44c38816ba03018bb1132021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352340921009318https://doaj.org/toc/2352-3409Understanding the mechanisms underlying the connection between somatic mosaicism and cardiovascular disease is likely essential for the future of personalized medicine. This article is aimed at providing data on somatic mosaicism in human carotid atherosclerosis. An advanced carotid atherosclerotic plaque and white blood cells were collected simultaneously from each patient (eight Slavic males, aged 67 ± 3.8 years [mean ± SD]) to assess the spectrum of germline and somatic genetic variants. Exome sequencing of DNA from the samples was performed with the SureSelect Clinical Research Exome Enrichment Kit (Agilent Technologies) and HiSeq 1500 (Illumina). The dataset contains germline and somatic single-nucleotide variants and small indels identified in the advanced carotid atherosclerotic plaque and white blood cells of each patient. This dataset does not include copy number variants owing to a lack of suitable tools for reliable calculation of copy numbers from exome sequencing data on cancer-unrelated samples. The dataset should help to understand somatic mosaicism in cardiovascular diseases and to identify copy number variants by means of more appropriate newer tools in the future.Alexei A. SleptcovAlexei A. ZarubinPolina M. BogaychukMikhail S. KuznetsovBoris N. KozlovMaria S. NazarenkoElsevierarticleAtherosclerosisCarotid plaqueExome sequencingHiSeqComputer applications to medicine. Medical informaticsR858-859.7Science (General)Q1-390ENData in Brief, Vol 39, Iss , Pp 107656- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Atherosclerosis Carotid plaque Exome sequencing HiSeq Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
spellingShingle	Atherosclerosis Carotid plaque Exome sequencing HiSeq Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390 Alexei A. Sleptcov Alexei A. Zarubin Polina M. Bogaychuk Mikhail S. Kuznetsov Boris N. Kozlov Maria S. Nazarenko Human exome sequence data in support of somatic mosaicism in carotid atherosclerosis
description	Understanding the mechanisms underlying the connection between somatic mosaicism and cardiovascular disease is likely essential for the future of personalized medicine. This article is aimed at providing data on somatic mosaicism in human carotid atherosclerosis. An advanced carotid atherosclerotic plaque and white blood cells were collected simultaneously from each patient (eight Slavic males, aged 67 ± 3.8 years [mean ± SD]) to assess the spectrum of germline and somatic genetic variants. Exome sequencing of DNA from the samples was performed with the SureSelect Clinical Research Exome Enrichment Kit (Agilent Technologies) and HiSeq 1500 (Illumina). The dataset contains germline and somatic single-nucleotide variants and small indels identified in the advanced carotid atherosclerotic plaque and white blood cells of each patient. This dataset does not include copy number variants owing to a lack of suitable tools for reliable calculation of copy numbers from exome sequencing data on cancer-unrelated samples. The dataset should help to understand somatic mosaicism in cardiovascular diseases and to identify copy number variants by means of more appropriate newer tools in the future.
format	article
author	Alexei A. Sleptcov Alexei A. Zarubin Polina M. Bogaychuk Mikhail S. Kuznetsov Boris N. Kozlov Maria S. Nazarenko
author_facet	Alexei A. Sleptcov Alexei A. Zarubin Polina M. Bogaychuk Mikhail S. Kuznetsov Boris N. Kozlov Maria S. Nazarenko
author_sort	Alexei A. Sleptcov
title	Human exome sequence data in support of somatic mosaicism in carotid atherosclerosis
title_short	Human exome sequence data in support of somatic mosaicism in carotid atherosclerosis
title_full	Human exome sequence data in support of somatic mosaicism in carotid atherosclerosis
title_fullStr	Human exome sequence data in support of somatic mosaicism in carotid atherosclerosis
title_full_unstemmed	Human exome sequence data in support of somatic mosaicism in carotid atherosclerosis
title_sort	human exome sequence data in support of somatic mosaicism in carotid atherosclerosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9dfae944c61d44c38816ba03018bb113
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Human exome sequence data in support of somatic mosaicism in carotid atherosclerosis

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