Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic...

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Autores principales:	Timo Burster, Zhadyra Mustafa, Dinara Myrzakhmetova, Anuar Zhanapiya, Michal Zimecki
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	serine protease inhibitors serine proteases neutrophil elastase proteinase 3 cathepsin G thrombosis Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9e010d1b5c704a3abf66bcde79779acf
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spelling	oai:doaj.org-article:9e010d1b5c704a3abf66bcde79779acf2021-11-15T05:18:30ZHindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation2296-264610.3389/fchem.2021.784003https://doaj.org/article/9e010d1b5c704a3abf66bcde79779acf2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.784003/fullhttps://doaj.org/toc/2296-2646During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.Timo BursterZhadyra MustafaDinara MyrzakhmetovaAnuar ZhanapiyaMichal ZimeckiFrontiers Media S.A.articleserine protease inhibitorsserine proteasesneutrophil elastaseproteinase 3cathepsin GthrombosisChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	serine protease inhibitors serine proteases neutrophil elastase proteinase 3 cathepsin G thrombosis Chemistry QD1-999
spellingShingle	serine protease inhibitors serine proteases neutrophil elastase proteinase 3 cathepsin G thrombosis Chemistry QD1-999 Timo Burster Zhadyra Mustafa Dinara Myrzakhmetova Anuar Zhanapiya Michal Zimecki Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
description	During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.
format	article
author	Timo Burster Zhadyra Mustafa Dinara Myrzakhmetova Anuar Zhanapiya Michal Zimecki
author_facet	Timo Burster Zhadyra Mustafa Dinara Myrzakhmetova Anuar Zhanapiya Michal Zimecki
author_sort	Timo Burster
title	Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
title_short	Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
title_full	Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
title_fullStr	Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
title_full_unstemmed	Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
title_sort	hindrance of the proteolytic activity of neutrophil-derived serine proteases by serine protease inhibitors as a management of cardiovascular diseases and chronic inflammation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9e010d1b5c704a3abf66bcde79779acf
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Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

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