The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5

Regulatory B (Breg) cells suppress excessive inflammation primary via the production of interleukin 10 (IL-10). Here the authors show that the function and homeostasis of mouse and human IL-10+ Breg cells are negatively regulated by the cell surface receptor, SLAMF5, to impact experimental autoimmun...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lihi Radomir, Matthias P. Kramer, Michal Perpinial, Nofar Schottlender, Stav Rabani, Keren David, Anna Wiener, Hadas Lewinsky, Shirly Becker-Herman, Rina Aharoni, Ron Milo, Claudia Mauri, Idit Shachar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e0225d58b0f4b71aa42bed1e5fd6e18
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e0225d58b0f4b71aa42bed1e5fd6e18
record_format	dspace
spelling	oai:doaj.org-article:9e0225d58b0f4b71aa42bed1e5fd6e182021-12-02T11:44:50ZThe survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF510.1038/s41467-021-22230-z2041-1723https://doaj.org/article/9e0225d58b0f4b71aa42bed1e5fd6e182021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22230-zhttps://doaj.org/toc/2041-1723Regulatory B (Breg) cells suppress excessive inflammation primary via the production of interleukin 10 (IL-10). Here the authors show that the function and homeostasis of mouse and human IL-10+ Breg cells are negatively regulated by the cell surface receptor, SLAMF5, to impact experimental autoimmunity, thereby hinting SLAMF5 as a potential target for immunotherapy.Lihi RadomirMatthias P. KramerMichal PerpinialNofar SchottlenderStav RabaniKeren DavidAnna WienerHadas LewinskyShirly Becker-HermanRina AharoniRon MiloClaudia MauriIdit ShacharNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lihi Radomir Matthias P. Kramer Michal Perpinial Nofar Schottlender Stav Rabani Keren David Anna Wiener Hadas Lewinsky Shirly Becker-Herman Rina Aharoni Ron Milo Claudia Mauri Idit Shachar The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5
description	Regulatory B (Breg) cells suppress excessive inflammation primary via the production of interleukin 10 (IL-10). Here the authors show that the function and homeostasis of mouse and human IL-10+ Breg cells are negatively regulated by the cell surface receptor, SLAMF5, to impact experimental autoimmunity, thereby hinting SLAMF5 as a potential target for immunotherapy.
format	article
author	Lihi Radomir Matthias P. Kramer Michal Perpinial Nofar Schottlender Stav Rabani Keren David Anna Wiener Hadas Lewinsky Shirly Becker-Herman Rina Aharoni Ron Milo Claudia Mauri Idit Shachar
author_facet	Lihi Radomir Matthias P. Kramer Michal Perpinial Nofar Schottlender Stav Rabani Keren David Anna Wiener Hadas Lewinsky Shirly Becker-Herman Rina Aharoni Ron Milo Claudia Mauri Idit Shachar
author_sort	Lihi Radomir
title	The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5
title_short	The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5
title_full	The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5
title_fullStr	The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5
title_full_unstemmed	The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5
title_sort	survival and function of il-10-producing regulatory b cells are negatively controlled by slamf5
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e0225d58b0f4b71aa42bed1e5fd6e18
work_keys_str_mv	AT lihiradomir thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT matthiaspkramer thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT michalperpinial thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT nofarschottlender thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT stavrabani thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT kerendavid thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT annawiener thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT hadaslewinsky thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT shirlybeckerherman thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT rinaaharoni thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT ronmilo thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT claudiamauri thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT iditshachar thesurvivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT lihiradomir survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT matthiaspkramer survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT michalperpinial survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT nofarschottlender survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT stavrabani survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT kerendavid survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT annawiener survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT hadaslewinsky survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT shirlybeckerherman survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT rinaaharoni survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT ronmilo survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT claudiamauri survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5 AT iditshachar survivalandfunctionofil10producingregulatorybcellsarenegativelycontrolledbyslamf5
_version_	1718395298747777024

The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5

Ejemplares similares