Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

The rTg4510 mosue line has a tauopathy-like phenotype which is attributed to overexpression of human tau in the frontal cortex. Here the authors identify potential confounding genetic factors that could contribute to the phenotype.

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Detalles Bibliográficos
Autores principales: Julia Gamache, Kellie Benzow, Colleen Forster, Lisa Kemper, Chris Hlynialuk, Eva Furrow, Karen H. Ashe, Michael D. Koob
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9e0243c9022847c19c905619188b6933
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Descripción
Sumario:The rTg4510 mosue line has a tauopathy-like phenotype which is attributed to overexpression of human tau in the frontal cortex. Here the authors identify potential confounding genetic factors that could contribute to the phenotype.