Systemic toxicity induced by aggregated layered double hydroxide nanoparticles

Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Higher Education Mega Center, Guangzhou, China Abstract: Layered double hydroxide (LDH) nanoparticles are emerging as one of the pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yan M, Yang C, Huang B, Huang Z, Huang L, Zhang X, Zhao C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	inorganic nanoparticles aggregation systemic toxicity layered double hydroxide Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9e0450cf0acf4596b149f15e749ca21a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e0450cf0acf4596b149f15e749ca21a
record_format	dspace
spelling	oai:doaj.org-article:9e0450cf0acf4596b149f15e749ca21a2021-12-02T06:32:31ZSystemic toxicity induced by aggregated layered double hydroxide nanoparticles1178-2013https://doaj.org/article/9e0450cf0acf4596b149f15e749ca21a2017-10-01T00:00:00Zhttps://www.dovepress.com/systemic-toxicity-induced-by-aggregated-layered-double-hydroxide-nanop-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Higher Education Mega Center, Guangzhou, China Abstract: Layered double hydroxide (LDH) nanoparticles are emerging as one of the promising nanomaterials for biomedical applications, but their systemic toxicity in vivo has received little attention. In the present study, the effects of inorganic nanoparticle aggregation on their systemic toxicity were examined. Remarkably, aggregation was observed after the mixing of naked LDH nanoparticles with saline or erythrocytes. Significant accumulation of the naked LDH nanoparticles in the lungs of mice was detected 1 h after intravenous administration, and the survival rate of mice was 0% after 6 repeated injections. Furthermore, flocculent precipitates in the alveoli and congestion in the lung interstitium were observed in the dead mice. However, lipid membrane-coated LDH nanoparticles would not form aggregates and could be injected intravenously >6 times without causing death. These findings suggested that repeated injections of LDH were lethal even at low dose (30 mg/kg), and lipid membrane coating can be considered as an approach for reducing this risk. Keywords: inorganic nanoparticles, aggregation, erythrocyte aggregation, repeated intravenous injection, pulmonary embolism, sudden deathYan MYang CHuang BHuang ZHuang LZhang XZhao CDove Medical Pressarticleinorganic nanoparticlesaggregationsystemic toxicitylayered double hydroxideMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7183-7195 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	inorganic nanoparticles aggregation systemic toxicity layered double hydroxide Medicine (General) R5-920
spellingShingle	inorganic nanoparticles aggregation systemic toxicity layered double hydroxide Medicine (General) R5-920 Yan M Yang C Huang B Huang Z Huang L Zhang X Zhao C Systemic toxicity induced by aggregated layered double hydroxide nanoparticles
description	Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Higher Education Mega Center, Guangzhou, China Abstract: Layered double hydroxide (LDH) nanoparticles are emerging as one of the promising nanomaterials for biomedical applications, but their systemic toxicity in vivo has received little attention. In the present study, the effects of inorganic nanoparticle aggregation on their systemic toxicity were examined. Remarkably, aggregation was observed after the mixing of naked LDH nanoparticles with saline or erythrocytes. Significant accumulation of the naked LDH nanoparticles in the lungs of mice was detected 1 h after intravenous administration, and the survival rate of mice was 0% after 6 repeated injections. Furthermore, flocculent precipitates in the alveoli and congestion in the lung interstitium were observed in the dead mice. However, lipid membrane-coated LDH nanoparticles would not form aggregates and could be injected intravenously >6 times without causing death. These findings suggested that repeated injections of LDH were lethal even at low dose (30 mg/kg), and lipid membrane coating can be considered as an approach for reducing this risk. Keywords: inorganic nanoparticles, aggregation, erythrocyte aggregation, repeated intravenous injection, pulmonary embolism, sudden death
format	article
author	Yan M Yang C Huang B Huang Z Huang L Zhang X Zhao C
author_facet	Yan M Yang C Huang B Huang Z Huang L Zhang X Zhao C
author_sort	Yan M
title	Systemic toxicity induced by aggregated layered double hydroxide nanoparticles
title_short	Systemic toxicity induced by aggregated layered double hydroxide nanoparticles
title_full	Systemic toxicity induced by aggregated layered double hydroxide nanoparticles
title_fullStr	Systemic toxicity induced by aggregated layered double hydroxide nanoparticles
title_full_unstemmed	Systemic toxicity induced by aggregated layered double hydroxide nanoparticles
title_sort	systemic toxicity induced by aggregated layered double hydroxide nanoparticles
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9e0450cf0acf4596b149f15e749ca21a
work_keys_str_mv	AT yanm systemictoxicityinducedbyaggregatedlayereddoublehydroxidenanoparticles AT yangc systemictoxicityinducedbyaggregatedlayereddoublehydroxidenanoparticles AT huangb systemictoxicityinducedbyaggregatedlayereddoublehydroxidenanoparticles AT huangz systemictoxicityinducedbyaggregatedlayereddoublehydroxidenanoparticles AT huangl systemictoxicityinducedbyaggregatedlayereddoublehydroxidenanoparticles AT zhangx systemictoxicityinducedbyaggregatedlayereddoublehydroxidenanoparticles AT zhaoc systemictoxicityinducedbyaggregatedlayereddoublehydroxidenanoparticles
_version_	1718399891648020480

Systemic toxicity induced by aggregated layered double hydroxide nanoparticles

Ejemplares similares