Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population

Abstract This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y...

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Autores principales:	Rossana Santiago de Sousa Azulay, Luís Cristóvão Porto, Dayse Aparecida Silva, Maria da Glória Tavares, Roberta Maria Duailibe Ferreira Reis, Gilvan Cortês Nascimento, Sabrina da Silva Pereira Damianse, Viviane Chaves de Carvalho Rocha, Marcelo Magalhães, Vandilson Rodrigues, Paulo Ricardo Vilas Boas Carvalho, Manuel dos Santos Faria, Marília Brito Gomes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e07cd2fd17c4a5fbf6ede1f70337d66
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spelling	oai:doaj.org-article:9e07cd2fd17c4a5fbf6ede1f70337d662021-12-02T16:15:06ZGenetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population10.1038/s41598-021-93691-x2045-2322https://doaj.org/article/9e07cd2fd17c4a5fbf6ede1f70337d662021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93691-xhttps://doaj.org/toc/2045-2322Abstract This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB103 and DRB104 alleles presented risk association with T1D. When the Y chromosome was European, DRB103 and DRB104 homozygote and DRB103/DRB104 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB103 and DRB104 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association.Rossana Santiago de Sousa AzulayLuís Cristóvão PortoDayse Aparecida SilvaMaria da Glória TavaresRoberta Maria Duailibe Ferreira ReisGilvan Cortês NascimentoSabrina da Silva Pereira DamianseViviane Chaves de Carvalho RochaMarcelo MagalhãesVandilson RodriguesPaulo Ricardo Vilas Boas CarvalhoManuel dos Santos FariaMarília Brito GomesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rossana Santiago de Sousa Azulay Luís Cristóvão Porto Dayse Aparecida Silva Maria da Glória Tavares Roberta Maria Duailibe Ferreira Reis Gilvan Cortês Nascimento Sabrina da Silva Pereira Damianse Viviane Chaves de Carvalho Rocha Marcelo Magalhães Vandilson Rodrigues Paulo Ricardo Vilas Boas Carvalho Manuel dos Santos Faria Marília Brito Gomes Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population
description	Abstract This study aimed to investigate the relationship between genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in patients with Type 1 Diabetes from an admixed Brazilian population. Inference of autosomal ancestry; HLA-DRB1, -DQA1 and -DQB1 typifications; and Y chromosome analysis were performed. European autosomal ancestry was about 50%, followed by approximately 25% of African and Native American. The European Y chromosome was predominant. The HLA-DRB103 and DRB104 alleles presented risk association with T1D. When the Y chromosome was European, DRB103 and DRB104 homozygote and DRB103/DRB104 heterozygote genotypes were the most frequent. The results suggest that individuals from Maranhão have a European origin as their major component; and are patrilineal with greater frequency from the R1b haplogroup. The predominance of the HLA-DRB103 and DRB104 alleles conferring greater risk in our population and being more frequently related to the ancestry of the European Y chromosome suggests that in our population, the risk of T1D can be transmitted by European ancestors of our process miscegenation. However, the Y sample sizes of Africans and Native Americans were small, and further research should be conducted with large mixed sample sizes to clarify this possible association.
format	article
author	Rossana Santiago de Sousa Azulay Luís Cristóvão Porto Dayse Aparecida Silva Maria da Glória Tavares Roberta Maria Duailibe Ferreira Reis Gilvan Cortês Nascimento Sabrina da Silva Pereira Damianse Viviane Chaves de Carvalho Rocha Marcelo Magalhães Vandilson Rodrigues Paulo Ricardo Vilas Boas Carvalho Manuel dos Santos Faria Marília Brito Gomes
author_facet	Rossana Santiago de Sousa Azulay Luís Cristóvão Porto Dayse Aparecida Silva Maria da Glória Tavares Roberta Maria Duailibe Ferreira Reis Gilvan Cortês Nascimento Sabrina da Silva Pereira Damianse Viviane Chaves de Carvalho Rocha Marcelo Magalhães Vandilson Rodrigues Paulo Ricardo Vilas Boas Carvalho Manuel dos Santos Faria Marília Brito Gomes
author_sort	Rossana Santiago de Sousa Azulay
title	Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population
title_short	Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population
title_full	Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population
title_fullStr	Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population
title_full_unstemmed	Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population
title_sort	genetic ancestry inferred from autosomal and y chromosome markers and hla genotypes in type 1 diabetes from an admixed brazilian population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e07cd2fd17c4a5fbf6ede1f70337d66
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Genetic ancestry inferred from autosomal and Y chromosome markers and HLA genotypes in Type 1 Diabetes from an admixed Brazilian population

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