Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study

Ping-Song Chou,1 Chiou-Lian Lai,1–3 Yii-Her Chou,4,5,* Wei-Pin Chang6,* 1Department of Neurology, Kaohsiung Medical University Hospital, 2Department of Neurology, Faculty of Medicine, College of Medicine, 3Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, 4Department of Ur...

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Autores principales: Chou PS, Lai CL, Chou YH, Chang WP
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Publicado: Dove Medical Press 2017
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spelling oai:doaj.org-article:9e0acbbb91fd44ca8c28cf087337bc412021-12-02T06:18:14ZSleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study1178-2021https://doaj.org/article/9e0acbbb91fd44ca8c28cf087337bc412017-03-01T00:00:00Zhttps://www.dovepress.com/sleep-apnea-and-the-subsequent-risk-of-parkinsonrsquos-disease-a-3-yea-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ping-Song Chou,1 Chiou-Lian Lai,1–3 Yii-Her Chou,4,5,* Wei-Pin Chang6,* 1Department of Neurology, Kaohsiung Medical University Hospital, 2Department of Neurology, Faculty of Medicine, College of Medicine, 3Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, 4Department of Urology, Faculty of Medicine, College of Medicine, 5Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 6School of Health Care Administration, Taipei Medical University, Taipei City, Taiwan *These authors contributed equally to this work Purpose: Sleep apnea (SA)-induced chronic intermittent hypoxia increases oxidative stress and inflammation, which may contribute to the pathophysiology of Parkinson’s disease (PD). This study evaluated the risk of PD following SA diagnosis.Patients and methods: This was a 3-year nationwide population-based matched cohort study using claims data from the National Health Insurance Research Database (NHIRD), Taiwan. We analyzed 1,944 patients diagnosed as having SA between 1997 and 2005 and a matched cohort of 9,720 non-SA patients from the NHIRD. Patients with a history of PD were excluded. Each patient was followed up for 3 years to evaluate subsequent PD development.Results: Of the 11,664 patients, 17 (0.9%) and 38 (0.4%) from the SA and matched non-SA cohorts, respectively, were subsequently diagnosed as having PD during follow-up. After adjustments for potential confounders, the SA cohort had a 1.85-fold higher risk of PD than the non-SA cohort (95% confidence interval [CI] =1.02–3.35; P=0.042). After age and sex stratification, PD development was independently associated with SA only in men (adjusted hazard ratio [HR], 2.26; 95% CI =1.11–4.63; P<0.05) and in patients aged ≥60 years (adjusted HR, 1.93; 95% CI =1.01–3.71; P<0.05).Conclusion: Our study suggests that patients with SA are at an increased longitudinal risk of PD. Furthermore, age and male sex are independently associated with the risk of PD. Keywords: cohort study, intermittent hypoxia, National Health Insurance Research Database, population-based studyChou PSLai CLChou YHChang WPDove Medical PressarticleCohort studyintermittent hypoxianational health insurance research databasepopulation-based studyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 959-965 (2017)
institution DOAJ
collection DOAJ
language EN
topic Cohort study
intermittent hypoxia
national health insurance research database
population-based study
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Cohort study
intermittent hypoxia
national health insurance research database
population-based study
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Chou PS
Lai CL
Chou YH
Chang WP
Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study
description Ping-Song Chou,1 Chiou-Lian Lai,1–3 Yii-Her Chou,4,5,* Wei-Pin Chang6,* 1Department of Neurology, Kaohsiung Medical University Hospital, 2Department of Neurology, Faculty of Medicine, College of Medicine, 3Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, 4Department of Urology, Faculty of Medicine, College of Medicine, 5Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 6School of Health Care Administration, Taipei Medical University, Taipei City, Taiwan *These authors contributed equally to this work Purpose: Sleep apnea (SA)-induced chronic intermittent hypoxia increases oxidative stress and inflammation, which may contribute to the pathophysiology of Parkinson’s disease (PD). This study evaluated the risk of PD following SA diagnosis.Patients and methods: This was a 3-year nationwide population-based matched cohort study using claims data from the National Health Insurance Research Database (NHIRD), Taiwan. We analyzed 1,944 patients diagnosed as having SA between 1997 and 2005 and a matched cohort of 9,720 non-SA patients from the NHIRD. Patients with a history of PD were excluded. Each patient was followed up for 3 years to evaluate subsequent PD development.Results: Of the 11,664 patients, 17 (0.9%) and 38 (0.4%) from the SA and matched non-SA cohorts, respectively, were subsequently diagnosed as having PD during follow-up. After adjustments for potential confounders, the SA cohort had a 1.85-fold higher risk of PD than the non-SA cohort (95% confidence interval [CI] =1.02–3.35; P=0.042). After age and sex stratification, PD development was independently associated with SA only in men (adjusted hazard ratio [HR], 2.26; 95% CI =1.11–4.63; P<0.05) and in patients aged ≥60 years (adjusted HR, 1.93; 95% CI =1.01–3.71; P<0.05).Conclusion: Our study suggests that patients with SA are at an increased longitudinal risk of PD. Furthermore, age and male sex are independently associated with the risk of PD. Keywords: cohort study, intermittent hypoxia, National Health Insurance Research Database, population-based study
format article
author Chou PS
Lai CL
Chou YH
Chang WP
author_facet Chou PS
Lai CL
Chou YH
Chang WP
author_sort Chou PS
title Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study
title_short Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study
title_full Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study
title_fullStr Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study
title_full_unstemmed Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study
title_sort sleep apnea and the subsequent risk of parkinson’s disease: a 3-year nationwide population-based study
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/9e0acbbb91fd44ca8c28cf087337bc41
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AT laicl sleepapneaandthesubsequentriskofparkinsonrsquosdiseasea3yearnationwidepopulationbasedstudy
AT chouyh sleepapneaandthesubsequentriskofparkinsonrsquosdiseasea3yearnationwidepopulationbasedstudy
AT changwp sleepapneaandthesubsequentriskofparkinsonrsquosdiseasea3yearnationwidepopulationbasedstudy
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