Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging

Abstract The purpose of the present study was to evaluate the intraretinal migration of the retinal pigment epithelium (RPE) cells in age-related macular degeneration (AMD) using polarimetry. We evaluated 155 eyes at various AMD stages. Depolarized light images were computed using a polarization-sen...

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Autores principales:	Masahiro Miura, Shuichi Makita, Satoshi Sugiyama, Young-Joo Hong, Yoshiaki Yasuno, Ann E. Elsner, Shigeo Tamiya, Rintaro Tsukahara, Takuya Iwasaki, Hiroshi Goto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e0c38ac81ed467dad942efd7caf9b1e
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spelling	oai:doaj.org-article:9e0c38ac81ed467dad942efd7caf9b1e2021-12-02T16:08:20ZEvaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging10.1038/s41598-017-03529-82045-2322https://doaj.org/article/9e0c38ac81ed467dad942efd7caf9b1e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03529-8https://doaj.org/toc/2045-2322Abstract The purpose of the present study was to evaluate the intraretinal migration of the retinal pigment epithelium (RPE) cells in age-related macular degeneration (AMD) using polarimetry. We evaluated 155 eyes at various AMD stages. Depolarized light images were computed using a polarization-sensitive scanning laser ophthalmoscope (PS-SLO), and the degree of polarization uniformity was calculated using polarization-sensitive optical coherence tomography (OCT). Each polarimetry image was compared with the corresponding autofluorescence (AF) images at 488 nm (SW-AF) and at 787 nm (NIR-AF). Intraretinal RPE migration was defined by the presence of depolarization at intraretinal hyperreflective foci on PS-SLO and PS-OCT images, and by the presence of hyper-AF on both NIR-AF and SW-AF images. RPE migration was detected in 52 of 155 eyes (33.5%) and was observed in drusenoid pigment epithelial detachment (PED) and serous PED with significantly higher frequencies than in other groups (P = 0.015). The volume of the migrated RPE cluster in serous PED was significantly correlated with the volume of the PED (R2 = 0.26; P = 0.011). Overall, our results showed that intraretinal RPE migrations occurred in various AMD stages, and that they occurred more commonly in eyes with serous and drusenoid PED.Masahiro MiuraShuichi MakitaSatoshi SugiyamaYoung-Joo HongYoshiaki YasunoAnn E. ElsnerShigeo TamiyaRintaro TsukaharaTakuya IwasakiHiroshi GotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masahiro Miura Shuichi Makita Satoshi Sugiyama Young-Joo Hong Yoshiaki Yasuno Ann E. Elsner Shigeo Tamiya Rintaro Tsukahara Takuya Iwasaki Hiroshi Goto Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging
description	Abstract The purpose of the present study was to evaluate the intraretinal migration of the retinal pigment epithelium (RPE) cells in age-related macular degeneration (AMD) using polarimetry. We evaluated 155 eyes at various AMD stages. Depolarized light images were computed using a polarization-sensitive scanning laser ophthalmoscope (PS-SLO), and the degree of polarization uniformity was calculated using polarization-sensitive optical coherence tomography (OCT). Each polarimetry image was compared with the corresponding autofluorescence (AF) images at 488 nm (SW-AF) and at 787 nm (NIR-AF). Intraretinal RPE migration was defined by the presence of depolarization at intraretinal hyperreflective foci on PS-SLO and PS-OCT images, and by the presence of hyper-AF on both NIR-AF and SW-AF images. RPE migration was detected in 52 of 155 eyes (33.5%) and was observed in drusenoid pigment epithelial detachment (PED) and serous PED with significantly higher frequencies than in other groups (P = 0.015). The volume of the migrated RPE cluster in serous PED was significantly correlated with the volume of the PED (R2 = 0.26; P = 0.011). Overall, our results showed that intraretinal RPE migrations occurred in various AMD stages, and that they occurred more commonly in eyes with serous and drusenoid PED.
format	article
author	Masahiro Miura Shuichi Makita Satoshi Sugiyama Young-Joo Hong Yoshiaki Yasuno Ann E. Elsner Shigeo Tamiya Rintaro Tsukahara Takuya Iwasaki Hiroshi Goto
author_facet	Masahiro Miura Shuichi Makita Satoshi Sugiyama Young-Joo Hong Yoshiaki Yasuno Ann E. Elsner Shigeo Tamiya Rintaro Tsukahara Takuya Iwasaki Hiroshi Goto
author_sort	Masahiro Miura
title	Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging
title_short	Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging
title_full	Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging
title_fullStr	Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging
title_full_unstemmed	Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging
title_sort	evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9e0c38ac81ed467dad942efd7caf9b1e
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Evaluation of intraretinal migration of retinal pigment epithelial cells in age-related macular degeneration using polarimetric imaging

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