Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.

<h4>Objective</h4>To use multilevel functional principal component analysis to exploit the information inherent in the shape of longitudinally sampled glucose curves during pregnancy, and to analyse the impact of glucose curve characteristics on neonatal birth weight, percentage fat and...

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Autores principales:	Kathrine Frey Frøslie, Jo Røislien, Elisabeth Qvigstad, Kristin Godang, Jens Bollerslev, Tore Henriksen, Marit B Veierød
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e10a3c7ed1a404abbee67e073d71f7d
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spelling	oai:doaj.org-article:9e10a3c7ed1a404abbee67e073d71f7d2021-11-18T08:28:36ZShape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.1932-620310.1371/journal.pone.0090798https://doaj.org/article/9e10a3c7ed1a404abbee67e073d71f7d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24619030/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To use multilevel functional principal component analysis to exploit the information inherent in the shape of longitudinally sampled glucose curves during pregnancy, and to analyse the impact of glucose curve characteristics on neonatal birth weight, percentage fat and cord blood C-peptide.<h4>Study design and setting</h4>A cohort study of healthy, pregnant women (n = 884). They underwent two oral glucose tolerance tests (gestational weeks 14-16 and 30-32), which gave two glucose curves per woman.<h4>Results</h4>Glucose values were higher, and peaked later in third trimester than in early pregnancy. The curve characteristic "general glucose level" accounted for 91% of the variation across visits, and 72% within visits. The curve characteristics "timing of postprandial peak", and "oscillating glucose levels" accounted for a larger part of the variation within visits (15% and 8%), than across visits (7% and <2%). A late postprandial peak during pregnancy, and high general glucose levels in third trimester had significant, positive effects on birth weight (p<0.05). Generally high glucose levels during pregnancy had a significant, positive impact on neonatal percentage fat (p = 0.04). High general glucose level in third trimester had a significant, positive impact on cord blood C-peptide (p = 0.004).<h4>Conclusion</h4>Shape information in entire OGTT curves provides significant physiological information of importance for several outcomes, and may contribute to the understanding of the metabolic changes during pregnancy.Kathrine Frey FrøslieJo RøislienElisabeth QvigstadKristin GodangJens BollerslevTore HenriksenMarit B VeierødPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90798 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kathrine Frey Frøslie Jo Røislien Elisabeth Qvigstad Kristin Godang Jens Bollerslev Tore Henriksen Marit B Veierød Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.
description	<h4>Objective</h4>To use multilevel functional principal component analysis to exploit the information inherent in the shape of longitudinally sampled glucose curves during pregnancy, and to analyse the impact of glucose curve characteristics on neonatal birth weight, percentage fat and cord blood C-peptide.<h4>Study design and setting</h4>A cohort study of healthy, pregnant women (n = 884). They underwent two oral glucose tolerance tests (gestational weeks 14-16 and 30-32), which gave two glucose curves per woman.<h4>Results</h4>Glucose values were higher, and peaked later in third trimester than in early pregnancy. The curve characteristic "general glucose level" accounted for 91% of the variation across visits, and 72% within visits. The curve characteristics "timing of postprandial peak", and "oscillating glucose levels" accounted for a larger part of the variation within visits (15% and 8%), than across visits (7% and <2%). A late postprandial peak during pregnancy, and high general glucose levels in third trimester had significant, positive effects on birth weight (p<0.05). Generally high glucose levels during pregnancy had a significant, positive impact on neonatal percentage fat (p = 0.04). High general glucose level in third trimester had a significant, positive impact on cord blood C-peptide (p = 0.004).<h4>Conclusion</h4>Shape information in entire OGTT curves provides significant physiological information of importance for several outcomes, and may contribute to the understanding of the metabolic changes during pregnancy.
format	article
author	Kathrine Frey Frøslie Jo Røislien Elisabeth Qvigstad Kristin Godang Jens Bollerslev Tore Henriksen Marit B Veierød
author_facet	Kathrine Frey Frøslie Jo Røislien Elisabeth Qvigstad Kristin Godang Jens Bollerslev Tore Henriksen Marit B Veierød
author_sort	Kathrine Frey Frøslie
title	Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.
title_short	Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.
title_full	Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.
title_fullStr	Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.
title_full_unstemmed	Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.
title_sort	shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/9e10a3c7ed1a404abbee67e073d71f7d
work_keys_str_mv	AT kathrinefreyfrøslie shapeinformationinrepeatedglucosecurvesduringpregnancyprovidedsignificantphysiologicalinformationforneonataloutcomes AT jorøislien shapeinformationinrepeatedglucosecurvesduringpregnancyprovidedsignificantphysiologicalinformationforneonataloutcomes AT elisabethqvigstad shapeinformationinrepeatedglucosecurvesduringpregnancyprovidedsignificantphysiologicalinformationforneonataloutcomes AT kristingodang shapeinformationinrepeatedglucosecurvesduringpregnancyprovidedsignificantphysiologicalinformationforneonataloutcomes AT jensbollerslev shapeinformationinrepeatedglucosecurvesduringpregnancyprovidedsignificantphysiologicalinformationforneonataloutcomes AT torehenriksen shapeinformationinrepeatedglucosecurvesduringpregnancyprovidedsignificantphysiologicalinformationforneonataloutcomes AT maritbveierød shapeinformationinrepeatedglucosecurvesduringpregnancyprovidedsignificantphysiologicalinformationforneonataloutcomes
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Shape information in repeated glucose curves during pregnancy provided significant physiological information for neonatal outcomes.

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