Molecular basis of essential thrombocythaemia in humans and dogs – a review

<b>A potential cause of essential thrombocythaemia can be seen as the V617F point mutation within Janus kinase 2. This mutation occurs in 60-70% of patients with this disease and is located in the domain acting as an inhibitor. It increases the enzymatic activity of JAK2 kinase and induces int...

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Autores principales:	Nicola Padzik, Małgorzata Szewczuk
Formato:	article
Lenguaje:	EN PL
Publicado:	Polish Society of Animal Production 2021
Materias:	myeloproliferative syndromes JAK2-V617F essential thrombocythaemia Zoology QL1-991
Acceso en línea:	https://doaj.org/article/9e1699cfd2e84ec78f01867596a1f248
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spelling	oai:doaj.org-article:9e1699cfd2e84ec78f01867596a1f2482021-11-10T16:55:44ZMolecular basis of essential thrombocythaemia in humans and dogs – a review1733-73052719-393410.5604/01.3001.0014.7548https://doaj.org/article/9e1699cfd2e84ec78f01867596a1f2482021-03-01T00:00:00Zhttp://zootechnical.com/gicid/01.3001.0014.7548http://zootechnical.com/gicid/pdf/01.3001.0014.7548https://doaj.org/toc/1733-7305https://doaj.org/toc/2719-3934<b>A potential cause of essential thrombocythaemia can be seen as the V617F point mutation within Janus kinase 2. This mutation occurs in 60-70% of patients with this disease and is located in the domain acting as an inhibitor. It increases the enzymatic activity of JAK2 kinase and induces intensified sensitivity of cells to cytokines. Identification of mutations in the JAK2 gene has made it possible to describe the molecular pathogenesis of myeloproliferative syndromes, which has enabled more accurate diagnosis and assisted in effective treatment. The significant similarity of the clinical, laboratory and morphological features of myeloproliferative syndromes (including essential thrombocythaemia) in animals and humans suggests that common signalling pathways within the JAK2 gene may be involved in the development of these diseases.</b> Nicola PadzikMałgorzata SzewczukPolish Society of Animal Productionarticlemyeloproliferative syndromesJAK2-V617Fessential thrombocythaemiaZoologyQL1-991ENPLRoczniki Naukowe Polskiego Towarzystwa Zootechnicznego, Vol 17, Iss 1, Pp 13-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN PL
topic	myeloproliferative syndromes JAK2-V617F essential thrombocythaemia Zoology QL1-991
spellingShingle	myeloproliferative syndromes JAK2-V617F essential thrombocythaemia Zoology QL1-991 Nicola Padzik Małgorzata Szewczuk Molecular basis of essential thrombocythaemia in humans and dogs – a review
description	<b>A potential cause of essential thrombocythaemia can be seen as the V617F point mutation within Janus kinase 2. This mutation occurs in 60-70% of patients with this disease and is located in the domain acting as an inhibitor. It increases the enzymatic activity of JAK2 kinase and induces intensified sensitivity of cells to cytokines. Identification of mutations in the JAK2 gene has made it possible to describe the molecular pathogenesis of myeloproliferative syndromes, which has enabled more accurate diagnosis and assisted in effective treatment. The significant similarity of the clinical, laboratory and morphological features of myeloproliferative syndromes (including essential thrombocythaemia) in animals and humans suggests that common signalling pathways within the JAK2 gene may be involved in the development of these diseases.</b>
format	article
author	Nicola Padzik Małgorzata Szewczuk
author_facet	Nicola Padzik Małgorzata Szewczuk
author_sort	Nicola Padzik
title	Molecular basis of essential thrombocythaemia in humans and dogs – a review
title_short	Molecular basis of essential thrombocythaemia in humans and dogs – a review
title_full	Molecular basis of essential thrombocythaemia in humans and dogs – a review
title_fullStr	Molecular basis of essential thrombocythaemia in humans and dogs – a review
title_full_unstemmed	Molecular basis of essential thrombocythaemia in humans and dogs – a review
title_sort	molecular basis of essential thrombocythaemia in humans and dogs – a review
publisher	Polish Society of Animal Production
publishDate	2021
url	https://doaj.org/article/9e1699cfd2e84ec78f01867596a1f248
work_keys_str_mv	AT nicolapadzik molecularbasisofessentialthrombocythaemiainhumansanddogsareview AT małgorzataszewczuk molecularbasisofessentialthrombocythaemiainhumansanddogsareview
_version_	1718439896187666432

Molecular basis of essential thrombocythaemia in humans and dogs – a review

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