Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.

<h4>Background & aim</h4>Liver fibrosis screening in primary care population is a major public health issue. The FIB-4 index is a simple non-invasive fibrosis test combining age, transaminases, platelets count, developed for the diagnosis of advanced fibrosis. The aim of our study wa...

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Autores principales:	Philippe Halfon, Christelle Ansaldi, Guillaume Penaranda, Laurent Chiche, Patrick Dukan, Chloé Stavris, Anne Plauzolles, Frédérique Retornaz, Marc Bourliere
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e178689a7a34834a9928cdac8edf6e2
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spelling	oai:doaj.org-article:9e178689a7a34834a9928cdac8edf6e22021-12-02T20:06:34ZProspective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.1932-620310.1371/journal.pone.0254939https://doaj.org/article/9e178689a7a34834a9928cdac8edf6e22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254939https://doaj.org/toc/1932-6203<h4>Background & aim</h4>Liver fibrosis screening in primary care population is a major public health issue. The FIB-4 index is a simple non-invasive fibrosis test combining age, transaminases, platelets count, developed for the diagnosis of advanced fibrosis. The aim of our study was to evaluate the interest of liver fibrosis screening using systematic calculation of FIB-4 in routine blood analysis.<h4>Methods</h4>Between December 2018 and May 2019, we conducted a prospective screening of liver fibrosis in 134 158 patients during a medical check-up including routine blood analysis. Among these patients, 29 707 had transaminases and platelets counts available and benefited from an automatic calculation of FIB-4. Results were obtained from 21 French clinical laboratories in the Bouches du Rhône region.<h4>Results</h4>Among the 29 707 patients, 2161 (7.3%) had a high risk of advanced fibrosis (FIB-4>2.67). Individual investigation of patients with FIB-4>2.67 allowed to screen 1268 (1268/2161: 58.7%) patients who were not managed for any liver disease.<h4>Conclusions</h4>This work demonstrates the interest of FIB-4 for the screening of liver fibrosis in primary care population. Although additional clinical validation study is required to determine the utility and applicability of Fib-4 to daily practice, our study strongly supports this easy-to-implement strategy using a simple Fib-4 measure resulting from the use of available routine test results.Philippe HalfonChristelle AnsaldiGuillaume PenarandaLaurent ChichePatrick DukanChloé StavrisAnne PlauzollesFrédérique RetornazMarc BourlierePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254939 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Philippe Halfon Christelle Ansaldi Guillaume Penaranda Laurent Chiche Patrick Dukan Chloé Stavris Anne Plauzolles Frédérique Retornaz Marc Bourliere Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.
description	<h4>Background & aim</h4>Liver fibrosis screening in primary care population is a major public health issue. The FIB-4 index is a simple non-invasive fibrosis test combining age, transaminases, platelets count, developed for the diagnosis of advanced fibrosis. The aim of our study was to evaluate the interest of liver fibrosis screening using systematic calculation of FIB-4 in routine blood analysis.<h4>Methods</h4>Between December 2018 and May 2019, we conducted a prospective screening of liver fibrosis in 134 158 patients during a medical check-up including routine blood analysis. Among these patients, 29 707 had transaminases and platelets counts available and benefited from an automatic calculation of FIB-4. Results were obtained from 21 French clinical laboratories in the Bouches du Rhône region.<h4>Results</h4>Among the 29 707 patients, 2161 (7.3%) had a high risk of advanced fibrosis (FIB-4>2.67). Individual investigation of patients with FIB-4>2.67 allowed to screen 1268 (1268/2161: 58.7%) patients who were not managed for any liver disease.<h4>Conclusions</h4>This work demonstrates the interest of FIB-4 for the screening of liver fibrosis in primary care population. Although additional clinical validation study is required to determine the utility and applicability of Fib-4 to daily practice, our study strongly supports this easy-to-implement strategy using a simple Fib-4 measure resulting from the use of available routine test results.
format	article
author	Philippe Halfon Christelle Ansaldi Guillaume Penaranda Laurent Chiche Patrick Dukan Chloé Stavris Anne Plauzolles Frédérique Retornaz Marc Bourliere
author_facet	Philippe Halfon Christelle Ansaldi Guillaume Penaranda Laurent Chiche Patrick Dukan Chloé Stavris Anne Plauzolles Frédérique Retornaz Marc Bourliere
author_sort	Philippe Halfon
title	Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.
title_short	Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.
title_full	Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.
title_fullStr	Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.
title_full_unstemmed	Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.
title_sort	prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9e178689a7a34834a9928cdac8edf6e2
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Prospective screening of liver fibrosis in a primary care cohort using systematic calculation of fib-4 in routine results.

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