Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions

Abstract Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored. Using trace amine-associated receptor 5 knockout (TAAR5-KO) mice, that express beta-galactosidase mapping its lo...

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Autores principales:	D. S. Kalinina, M. A. Ptukha, A. V. Goriainova, N. S. Merkulyeva, A. A. Kozlova, R. Z. Murtazina, T. S. Shemiakova, S. R. Kuvarzin, A. N. Vaganova, A. B. Volnova, R. R. Gainetdinov, P. E. Musienko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e17d42ecfb348b8bf9d35ba92c61951
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spelling	oai:doaj.org-article:9e17d42ecfb348b8bf9d35ba92c619512021-12-05T12:11:40ZRole of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions10.1038/s41598-021-02289-w2045-2322https://doaj.org/article/9e17d42ecfb348b8bf9d35ba92c619512021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02289-whttps://doaj.org/toc/2045-2322Abstract Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored. Using trace amine-associated receptor 5 knockout (TAAR5-KO) mice, that express beta-galactosidase mapping its localization, we observed TAAR5 expression in the Purkinje cells of the cerebellum and the medial vestibular nucleus, suggesting that TAAR5 might be involved in the vestibular and motor control. Accordingly, in various behavioral tests, TAAR5-KO mice demonstrated lower endurance, but better coordination and balance compared to wild-type controls. Furthermore, we found specific changes in striatal local field potentials and motor cortex electrocorticogram, such as a decrease in delta and an increase in theta oscillations of power spectra, respectively. The obtained data indicate that TAAR5 plays a considerable role in regulation postural stability, muscle force, balance, and motor coordination during active movements, likely via modulation of monoaminergic systems at different levels of sensorimotor control involving critical brain areas such as the brainstem, cerebellum, and forebrain.D. S. KalininaM. A. PtukhaA. V. GoriainovaN. S. MerkulyevaA. A. KozlovaR. Z. MurtazinaT. S. ShemiakovaS. R. KuvarzinA. N. VaganovaA. B. VolnovaR. R. GainetdinovP. E. MusienkoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. S. Kalinina M. A. Ptukha A. V. Goriainova N. S. Merkulyeva A. A. Kozlova R. Z. Murtazina T. S. Shemiakova S. R. Kuvarzin A. N. Vaganova A. B. Volnova R. R. Gainetdinov P. E. Musienko Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
description	Abstract Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored. Using trace amine-associated receptor 5 knockout (TAAR5-KO) mice, that express beta-galactosidase mapping its localization, we observed TAAR5 expression in the Purkinje cells of the cerebellum and the medial vestibular nucleus, suggesting that TAAR5 might be involved in the vestibular and motor control. Accordingly, in various behavioral tests, TAAR5-KO mice demonstrated lower endurance, but better coordination and balance compared to wild-type controls. Furthermore, we found specific changes in striatal local field potentials and motor cortex electrocorticogram, such as a decrease in delta and an increase in theta oscillations of power spectra, respectively. The obtained data indicate that TAAR5 plays a considerable role in regulation postural stability, muscle force, balance, and motor coordination during active movements, likely via modulation of monoaminergic systems at different levels of sensorimotor control involving critical brain areas such as the brainstem, cerebellum, and forebrain.
format	article
author	D. S. Kalinina M. A. Ptukha A. V. Goriainova N. S. Merkulyeva A. A. Kozlova R. Z. Murtazina T. S. Shemiakova S. R. Kuvarzin A. N. Vaganova A. B. Volnova R. R. Gainetdinov P. E. Musienko
author_facet	D. S. Kalinina M. A. Ptukha A. V. Goriainova N. S. Merkulyeva A. A. Kozlova R. Z. Murtazina T. S. Shemiakova S. R. Kuvarzin A. N. Vaganova A. B. Volnova R. R. Gainetdinov P. E. Musienko
author_sort	D. S. Kalinina
title	Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_short	Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_full	Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_fullStr	Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_full_unstemmed	Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions
title_sort	role of the trace amine associated receptor 5 (taar5) in the sensorimotor functions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e17d42ecfb348b8bf9d35ba92c61951
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Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions

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