Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation

Pyruvate kinase phosphorylates histone H3T11 (H3pT11) and represses gene expression by forming a large complex SESAME (Serine-responsive SAM-containing Metabolic Enzyme). Here the authors show that SESAME-catalyzed H3pT11 regulates telomere silencing by promoting Sir2 binding at telomeres and preven...

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Autores principales:	Shihao Zhang, Xilan Yu, Yuan Zhang, Xiangyan Xue, Qi Yu, Zitong Zha, Madelaine Gogol, Jerry L. Workman, Shanshan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e1bd0d0532546299ffe3623112e7b14
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spelling	oai:doaj.org-article:9e1bd0d0532546299ffe3623112e7b142021-12-02T13:24:04ZMetabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation10.1038/s41467-020-20711-12041-1723https://doaj.org/article/9e1bd0d0532546299ffe3623112e7b142021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20711-1https://doaj.org/toc/2041-1723Pyruvate kinase phosphorylates histone H3T11 (H3pT11) and represses gene expression by forming a large complex SESAME (Serine-responsive SAM-containing Metabolic Enzyme). Here the authors show that SESAME-catalyzed H3pT11 regulates telomere silencing by promoting Sir2 binding at telomeres and preventing autophagy-mediated Sir2 degradation.Shihao ZhangXilan YuYuan ZhangXiangyan XueQi YuZitong ZhaMadelaine GogolJerry L. WorkmanShanshan LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shihao Zhang Xilan Yu Yuan Zhang Xiangyan Xue Qi Yu Zitong Zha Madelaine Gogol Jerry L. Workman Shanshan Li Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation
description	Pyruvate kinase phosphorylates histone H3T11 (H3pT11) and represses gene expression by forming a large complex SESAME (Serine-responsive SAM-containing Metabolic Enzyme). Here the authors show that SESAME-catalyzed H3pT11 regulates telomere silencing by promoting Sir2 binding at telomeres and preventing autophagy-mediated Sir2 degradation.
format	article
author	Shihao Zhang Xilan Yu Yuan Zhang Xiangyan Xue Qi Yu Zitong Zha Madelaine Gogol Jerry L. Workman Shanshan Li
author_facet	Shihao Zhang Xilan Yu Yuan Zhang Xiangyan Xue Qi Yu Zitong Zha Madelaine Gogol Jerry L. Workman Shanshan Li
author_sort	Shihao Zhang
title	Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation
title_short	Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation
title_full	Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation
title_fullStr	Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation
title_full_unstemmed	Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation
title_sort	metabolic regulation of telomere silencing by sesame complex-catalyzed h3t11 phosphorylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e1bd0d0532546299ffe3623112e7b14
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Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation

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