Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat

Brown adipocytes contribute to energy balance, and adipocyte development and brown adipocyte thermogenesis are in part regulated by epigenetic modifications. Here the authors report that the histone demethylase Utx maintains brown adipocyte identity via demethylation of PRDM16, which in turn repress...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fenfen Li, Jia Jing, Miranda Movahed, Xin Cui, Qiang Cao, Rui Wu, Ziyue Chen, Liqing Yu, Yi Pan, Huidong Shi, Hang Shi, Bingzhong Xue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e1c665d859844b1bc78ae334cecc799
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9e1c665d859844b1bc78ae334cecc799
record_format	dspace
spelling	oai:doaj.org-article:9e1c665d859844b1bc78ae334cecc7992021-11-28T12:33:02ZEpigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat10.1038/s41467-021-27141-72041-1723https://doaj.org/article/9e1c665d859844b1bc78ae334cecc7992021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27141-7https://doaj.org/toc/2041-1723Brown adipocytes contribute to energy balance, and adipocyte development and brown adipocyte thermogenesis are in part regulated by epigenetic modifications. Here the authors report that the histone demethylase Utx maintains brown adipocyte identity via demethylation of PRDM16, which in turn represses myogenic remodelling via DNMT1-mediated Myod1 promoter hypermethylation in mice.Fenfen LiJia JingMiranda MovahedXin CuiQiang CaoRui WuZiyue ChenLiqing YuYi PanHuidong ShiHang ShiBingzhong XueNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fenfen Li Jia Jing Miranda Movahed Xin Cui Qiang Cao Rui Wu Ziyue Chen Liqing Yu Yi Pan Huidong Shi Hang Shi Bingzhong Xue Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
description	Brown adipocytes contribute to energy balance, and adipocyte development and brown adipocyte thermogenesis are in part regulated by epigenetic modifications. Here the authors report that the histone demethylase Utx maintains brown adipocyte identity via demethylation of PRDM16, which in turn represses myogenic remodelling via DNMT1-mediated Myod1 promoter hypermethylation in mice.
format	article
author	Fenfen Li Jia Jing Miranda Movahed Xin Cui Qiang Cao Rui Wu Ziyue Chen Liqing Yu Yi Pan Huidong Shi Hang Shi Bingzhong Xue
author_facet	Fenfen Li Jia Jing Miranda Movahed Xin Cui Qiang Cao Rui Wu Ziyue Chen Liqing Yu Yi Pan Huidong Shi Hang Shi Bingzhong Xue
author_sort	Fenfen Li
title	Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
title_short	Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
title_full	Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
title_fullStr	Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
title_full_unstemmed	Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat
title_sort	epigenetic interaction between utx and dnmt1 regulates diet-induced myogenic remodeling in brown fat
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e1c665d859844b1bc78ae334cecc799
work_keys_str_mv	AT fenfenli epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT jiajing epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT mirandamovahed epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT xincui epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT qiangcao epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT ruiwu epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT ziyuechen epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT liqingyu epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT yipan epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT huidongshi epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT hangshi epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat AT bingzhongxue epigeneticinteractionbetweenutxanddnmt1regulatesdietinducedmyogenicremodelinginbrownfat
_version_	1718407907610984448

Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat

Ejemplares similares