Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease

Abstract Obstructive sleep apnea (OSA) is a recognized risk factor for the development of diabetic kidney disease (DKD). Our objectives were to compare the urinary albumin–creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) of patients with DKD according to OSA severity, and to e...

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Autores principales:	Ester Zamarrón, Ana Jaureguizar, Aldara García-Sánchez, Trinidad Díaz-Cambriles, Alberto Alonso-Fernández, Vanesa Lores, Olga Mediano, Paula Rodríguez-Rodríguez, Sheila Cabello-Pelegrín, Enrique Morales-Ruíz, María T. Ramírez-Prieto, María Isabel Valiente-Díaz, Teresa Gómez-García, Francisco García-Río, Spanish Sleep Network
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e1ce006d243420e88d9566358de64b6
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spelling	oai:doaj.org-article:9e1ce006d243420e88d9566358de64b62021-12-02T11:37:21ZObstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease10.1038/s41598-021-85023-w2045-2322https://doaj.org/article/9e1ce006d243420e88d9566358de64b62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85023-whttps://doaj.org/toc/2045-2322Abstract Obstructive sleep apnea (OSA) is a recognized risk factor for the development of diabetic kidney disease (DKD). Our objectives were to compare the urinary albumin–creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) of patients with DKD according to OSA severity, and to evaluate the contribution of sleep parameters to their renal function. In a multicenter, observational, cross-sectional study, 214 patients with DKD were recruited. After a sleep study, UACR and eGFR were measured, as well as serum creatinine, fasting glucose, glycated hemoglobin, insulin resistance, lipid profile and C-reactive protein. UACR was higher in severe OSA patients (920 ± 1053 mg/g) than in moderate (195 ± 232 mg/g, p < 0.001) or mild OSA/non-OSA subjects (119 ± 186 mg/g, p < 0.001). At the same time, eGFR showed an OSA severity-dependent reduction (48 ± 23 vs. 59 ± 21 vs. 73 ± 19 ml/min per 1.73 m2, respectively; p < 0.001). Apnea–hypopnea index (AHI and desaturation index (ODI) were identified as independent predictors for UACR and eGFR, respectively. Therefore, in patients with DKD under optimized treatment, severe OSA is associated with a higher UACR and a lower eGFR, reflecting an additional contribution to the impairment of their renal function, although no causality can be inferred.Ester ZamarrónAna JaureguizarAldara García-SánchezTrinidad Díaz-CambrilesAlberto Alonso-FernándezVanesa LoresOlga MedianoPaula Rodríguez-RodríguezSheila Cabello-PelegrínEnrique Morales-RuízMaría T. Ramírez-PrietoMaría Isabel Valiente-DíazTeresa Gómez-GarcíaFrancisco García-RíoSpanish Sleep NetworkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ester Zamarrón Ana Jaureguizar Aldara García-Sánchez Trinidad Díaz-Cambriles Alberto Alonso-Fernández Vanesa Lores Olga Mediano Paula Rodríguez-Rodríguez Sheila Cabello-Pelegrín Enrique Morales-Ruíz María T. Ramírez-Prieto María Isabel Valiente-Díaz Teresa Gómez-García Francisco García-Río Spanish Sleep Network Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease
description	Abstract Obstructive sleep apnea (OSA) is a recognized risk factor for the development of diabetic kidney disease (DKD). Our objectives were to compare the urinary albumin–creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) of patients with DKD according to OSA severity, and to evaluate the contribution of sleep parameters to their renal function. In a multicenter, observational, cross-sectional study, 214 patients with DKD were recruited. After a sleep study, UACR and eGFR were measured, as well as serum creatinine, fasting glucose, glycated hemoglobin, insulin resistance, lipid profile and C-reactive protein. UACR was higher in severe OSA patients (920 ± 1053 mg/g) than in moderate (195 ± 232 mg/g, p < 0.001) or mild OSA/non-OSA subjects (119 ± 186 mg/g, p < 0.001). At the same time, eGFR showed an OSA severity-dependent reduction (48 ± 23 vs. 59 ± 21 vs. 73 ± 19 ml/min per 1.73 m2, respectively; p < 0.001). Apnea–hypopnea index (AHI and desaturation index (ODI) were identified as independent predictors for UACR and eGFR, respectively. Therefore, in patients with DKD under optimized treatment, severe OSA is associated with a higher UACR and a lower eGFR, reflecting an additional contribution to the impairment of their renal function, although no causality can be inferred.
format	article
author	Ester Zamarrón Ana Jaureguizar Aldara García-Sánchez Trinidad Díaz-Cambriles Alberto Alonso-Fernández Vanesa Lores Olga Mediano Paula Rodríguez-Rodríguez Sheila Cabello-Pelegrín Enrique Morales-Ruíz María T. Ramírez-Prieto María Isabel Valiente-Díaz Teresa Gómez-García Francisco García-Río Spanish Sleep Network
author_facet	Ester Zamarrón Ana Jaureguizar Aldara García-Sánchez Trinidad Díaz-Cambriles Alberto Alonso-Fernández Vanesa Lores Olga Mediano Paula Rodríguez-Rodríguez Sheila Cabello-Pelegrín Enrique Morales-Ruíz María T. Ramírez-Prieto María Isabel Valiente-Díaz Teresa Gómez-García Francisco García-Río Spanish Sleep Network
author_sort	Ester Zamarrón
title	Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease
title_short	Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease
title_full	Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease
title_fullStr	Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease
title_full_unstemmed	Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease
title_sort	obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9e1ce006d243420e88d9566358de64b6
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Obstructive sleep apnea is associated with impaired renal function in patients with diabetic kidney disease

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