Axon guidance of sympathetic neurons to cardiomyocytes by glial cell line-derived neurotrophic factor (GDNF).
Molecular signaling of cardiac autonomic innervation is an unresolved issue. Here, we show that glial cell line-derived neurotrophic factor (GDNF) promotes cardiac sympathetic innervation in vitro and in vivo. In vitro, ventricular myocytes (VMs) and sympathetic neurons (SNs) isolated from neonatal...
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Main Authors: | Keiko Miwa, Jong-Kook Lee, Yoshiko Takagishi, Tobias Opthof, Xianming Fu, Masumi Hirabayashi, Kazuhiko Watabe, Yasuhiko Jimbo, Itsuo Kodama, Issei Komuro |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2013
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Online Access: | https://doaj.org/article/9e1e10d72205481caed266be9edb0950 |
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