Axon guidance of sympathetic neurons to cardiomyocytes by glial cell line-derived neurotrophic factor (GDNF).

Axon guidance of sympathetic neurons to cardiomyocytes by glial cell line-derived neurotrophic factor (GDNF).

Molecular signaling of cardiac autonomic innervation is an unresolved issue. Here, we show that glial cell line-derived neurotrophic factor (GDNF) promotes cardiac sympathetic innervation in vitro and in vivo. In vitro, ventricular myocytes (VMs) and sympathetic neurons (SNs) isolated from neonatal...

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Autores principales: Keiko Miwa, Jong-Kook Lee, Yoshiko Takagishi, Tobias Opthof, Xianming Fu, Masumi Hirabayashi, Kazuhiko Watabe, Yasuhiko Jimbo, Itsuo Kodama, Issei Komuro
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9e1e10d72205481caed266be9edb0950
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