Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment

Abstract A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morp...

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Autores principales:	Zhen Li, Ying Peng, Xingyu Xia, Zhe Cao, Yuqing Deng, Bin Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9e1f14f3ab3546ca89a23238a1f42c06
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spelling	oai:doaj.org-article:9e1f14f3ab3546ca89a23238a1f42c062021-12-02T15:09:47ZSr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment10.1038/s41598-019-54147-52045-2322https://doaj.org/article/9e1f14f3ab3546ca89a23238a1f42c062019-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-54147-5https://doaj.org/toc/2045-2322Abstract A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology and structure, and chemical and thermal stability. Ketoprofen was successfully loaded on the MOF carrier, which had been identified by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The release experiment manifested that more than 90% of ketoprofen released from Sr/PTA-MOF after 24 h, and ketoprofen delivery was mainly governed by the Higuchi model. Furthermore, cytotoxicity experiment manifested that synthesized MOF carrier had no poisonous effect on OA chondrocytes, which provided a preliminary foundation for the realization of comprehensive treating OA.Zhen LiYing PengXingyu XiaZhe CaoYuqing DengBin TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhen Li Ying Peng Xingyu Xia Zhe Cao Yuqing Deng Bin Tang Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
description	Abstract A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology and structure, and chemical and thermal stability. Ketoprofen was successfully loaded on the MOF carrier, which had been identified by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The release experiment manifested that more than 90% of ketoprofen released from Sr/PTA-MOF after 24 h, and ketoprofen delivery was mainly governed by the Higuchi model. Furthermore, cytotoxicity experiment manifested that synthesized MOF carrier had no poisonous effect on OA chondrocytes, which provided a preliminary foundation for the realization of comprehensive treating OA.
format	article
author	Zhen Li Ying Peng Xingyu Xia Zhe Cao Yuqing Deng Bin Tang
author_facet	Zhen Li Ying Peng Xingyu Xia Zhe Cao Yuqing Deng Bin Tang
author_sort	Zhen Li
title	Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_short	Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_full	Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_fullStr	Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_full_unstemmed	Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment
title_sort	sr/pta metal organic framework as a drug delivery system for osteoarthritis treatment
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9e1f14f3ab3546ca89a23238a1f42c06
work_keys_str_mv	AT zhenli srptametalorganicframeworkasadrugdeliverysystemforosteoarthritistreatment AT yingpeng srptametalorganicframeworkasadrugdeliverysystemforosteoarthritistreatment AT xingyuxia srptametalorganicframeworkasadrugdeliverysystemforosteoarthritistreatment AT zhecao srptametalorganicframeworkasadrugdeliverysystemforosteoarthritistreatment AT yuqingdeng srptametalorganicframeworkasadrugdeliverysystemforosteoarthritistreatment AT bintang srptametalorganicframeworkasadrugdeliverysystemforosteoarthritistreatment
_version_	1718387768861655040

Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment

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