Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review

The interconnection of nanotechnology and medicine could lead to improved materials, offering a better quality of life and new opportunities for biomedical applications, moving from research to clinical applications. Magnetite nanoparticles are interesting magnetic nanomaterials because of the prope...

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Autores principales:	Angela Spoială, Cornelia-Ioana Ilie, Luminița Narcisa Crăciun, Denisa Ficai, Anton Ficai, Ecaterina Andronescu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnetite-silica core/shell nanostructures biomedical application Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9e21765f71a74bb9879071004165f218
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spelling	oai:doaj.org-article:9e21765f71a74bb9879071004165f2182021-11-25T16:43:46ZMagnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review10.3390/app1122110752076-3417https://doaj.org/article/9e21765f71a74bb9879071004165f2182021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/11075https://doaj.org/toc/2076-3417The interconnection of nanotechnology and medicine could lead to improved materials, offering a better quality of life and new opportunities for biomedical applications, moving from research to clinical applications. Magnetite nanoparticles are interesting magnetic nanomaterials because of the property-depending methods chosen for their synthesis. Magnetite nanoparticles can be coated with various materials, resulting in “core/shell” magnetic structures with tunable properties. To synthesize promising materials with promising implications for biomedical applications, the researchers functionalized magnetite nanoparticles with silica and, thanks to the presence of silanol groups, the functionality, biocompatibility, and hydrophilicity were improved. This review highlights the most important synthesis methods for silica-coated with magnetite nanoparticles. From the presented methods, the most used was the Stöber method; there are also other syntheses presented in the review, such as co-precipitation, sol-gel, thermal decomposition, and the hydrothermal method. The second part of the review presents the main applications of magnetite-silica core/shell nanostructures. Magnetite-silica core/shell nanostructures have promising biomedical applications in magnetic resonance imaging (MRI) as a contrast agent, hyperthermia, drug delivery systems, and selective cancer therapy but also in developing magnetic micro devices.Angela SpoialăCornelia-Ioana IlieLuminița Narcisa CrăciunDenisa FicaiAnton FicaiEcaterina AndronescuMDPI AGarticlemagnetite-silicacore/shell nanostructuresbiomedical applicationTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 11075, p 11075 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetite-silica core/shell nanostructures biomedical application Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	magnetite-silica core/shell nanostructures biomedical application Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Angela Spoială Cornelia-Ioana Ilie Luminița Narcisa Crăciun Denisa Ficai Anton Ficai Ecaterina Andronescu Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review
description	The interconnection of nanotechnology and medicine could lead to improved materials, offering a better quality of life and new opportunities for biomedical applications, moving from research to clinical applications. Magnetite nanoparticles are interesting magnetic nanomaterials because of the property-depending methods chosen for their synthesis. Magnetite nanoparticles can be coated with various materials, resulting in “core/shell” magnetic structures with tunable properties. To synthesize promising materials with promising implications for biomedical applications, the researchers functionalized magnetite nanoparticles with silica and, thanks to the presence of silanol groups, the functionality, biocompatibility, and hydrophilicity were improved. This review highlights the most important synthesis methods for silica-coated with magnetite nanoparticles. From the presented methods, the most used was the Stöber method; there are also other syntheses presented in the review, such as co-precipitation, sol-gel, thermal decomposition, and the hydrothermal method. The second part of the review presents the main applications of magnetite-silica core/shell nanostructures. Magnetite-silica core/shell nanostructures have promising biomedical applications in magnetic resonance imaging (MRI) as a contrast agent, hyperthermia, drug delivery systems, and selective cancer therapy but also in developing magnetic micro devices.
format	article
author	Angela Spoială Cornelia-Ioana Ilie Luminița Narcisa Crăciun Denisa Ficai Anton Ficai Ecaterina Andronescu
author_facet	Angela Spoială Cornelia-Ioana Ilie Luminița Narcisa Crăciun Denisa Ficai Anton Ficai Ecaterina Andronescu
author_sort	Angela Spoială
title	Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review
title_short	Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review
title_full	Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review
title_fullStr	Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review
title_full_unstemmed	Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review
title_sort	magnetite-silica core/shell nanostructures: from surface functionalization towards biomedical applications—a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9e21765f71a74bb9879071004165f218
work_keys_str_mv	AT angelaspoiala magnetitesilicacoreshellnanostructuresfromsurfacefunctionalizationtowardsbiomedicalapplicationsareview AT corneliaioanailie magnetitesilicacoreshellnanostructuresfromsurfacefunctionalizationtowardsbiomedicalapplicationsareview AT luminitanarcisacraciun magnetitesilicacoreshellnanostructuresfromsurfacefunctionalizationtowardsbiomedicalapplicationsareview AT denisaficai magnetitesilicacoreshellnanostructuresfromsurfacefunctionalizationtowardsbiomedicalapplicationsareview AT antonficai magnetitesilicacoreshellnanostructuresfromsurfacefunctionalizationtowardsbiomedicalapplicationsareview AT ecaterinaandronescu magnetitesilicacoreshellnanostructuresfromsurfacefunctionalizationtowardsbiomedicalapplicationsareview
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Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review

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